Léonard A, Gerber G B
Mammalian Genetics Laboratory, C.E.N.-S.C.K., Mol, Belgium.
Mutat Res. 1988 Nov;196(3):247-57. doi: 10.1016/0165-1110(88)90009-7.
Aluminium and its salts, which are extensively used in the household and in industry, do not constitute a carcinogenic, mutagenic or teratogenic hazard, except, perhaps, in cases of extremely high exposure. The large majority of the experiments performed to assess the carcinogenicity of aluminium in laboratory animals gave negative results or even suggested some antitumor activity. Moreover, epidemiological studies have not provided clear evidence of a carcinogenic hazard of aluminium to man, and short-term tests made in vitro and in vivo to demonstrate mutagenic activity of A1 were negative except for some experiments in plants. The embryotoxic properties suggested by the studies on birds and mammals could result from the influence of A1 on phosphate and calcium metabolism or from interference with the polymerization of microtubules.
铝及其盐类在家庭和工业中广泛使用，除了在极高暴露的情况下，它们不构成致癌、致突变或致畸危害。为评估铝在实验动物中的致癌性而进行的绝大多数实验都得出了阴性结果，甚至还显示出一些抗肿瘤活性。此外，流行病学研究并未提供铝对人类致癌危害的明确证据，并且除了在植物中进行的一些实验外，体外和体内的短期试验表明铝没有致突变活性。对鸟类和哺乳动物的研究表明的胚胎毒性可能是由于铝对磷和钙代谢的影响，或者是由于对微管聚合的干扰。
