Léonard A, Gerber G B, Léonard F
Mutat Res. 1986 Nov;168(3):343-53. doi: 10.1016/0165-1110(86)90026-6.
Zinc is a common element in the human environment and constitutes an important trace element intervening in many biological processes. Toxicity of zinc is low; zinc deficiency represents, however, a hazard for human health. Zinc is not mutagenic and has little, if any, clastogenic properties. Zinc can induce tumours but only following local application, and does not represent a carcinogenic risk to man. It is still uncertain whether zinc can cause malignant transformation but zinc is needed for cellular proliferation of existing tumours and tumour growth is retarded by zinc deficiency. Zinc is not teratogenic; it can, in fact, avert teratogenicity of other agents. Conversely, zinc deficiency may be harmful to the developing organism.
锌是人类环境中的一种常见元素，是参与许多生物过程的重要微量元素。锌的毒性较低；然而，锌缺乏对人类健康构成危害。锌没有致突变性，即使有，其断裂剂特性也很弱。锌可诱发肿瘤，但仅在局部应用后才会发生，对人类不构成致癌风险。锌是否会导致恶性转化仍不确定，但现有肿瘤的细胞增殖需要锌，而锌缺乏会阻碍肿瘤生长。锌没有致畸性；事实上，它可以避免其他物质的致畸性。相反，锌缺乏可能对发育中的生物体有害。
