School of Environment and Sustainability, University of Saskatchewan, 117 Science Place Saskatoon, Saskatoon, SK S7N 5C8, Canada; Global Institute for Water Security, University of Saskatchewan, Innovation Blvd, Saskatoon, SK S7N 3H5, Canada.
Toxicology Centre, University of Saskatchewan, 44 Campus Dr, Saskatoon, SK S7N 5B3, Canada.
Sci Total Environ. 2022 Dec 10;851(Pt 2):158247. doi: 10.1016/j.scitotenv.2022.158247. Epub 2022 Aug 23.
Most pharmaceuticals are found at trace concentrations in aquatic systems, but their continuous release and potential accumulation can lead to adverse health effects in exposed organisms. Concentrations can vary temporally, driven by variations in discharges of receiving waters, sorption to sediments, and other biotic and abiotic exchange processes. The principal aim of this research was to better understand the occurrence, trends, and dynamics of pharmaceuticals in a cold-climate, riverine environment. To this end, a suite of seven representative antipsychotic pharmaceuticals was measured upstream and downstream of two wastewater treatment plants (WWTPs) in Saskatchewan, Canada, located in the South Saskatchewan River and Wascana Creek, respectively, across three seasons. Concentrations of analytes were in the ng/L range and generally greater downstream of both WWTPs compared to upstream. Some compounds, including the tricyclic antidepressant amitriptyline, which was the most abundant analyte in water and sediment from both sites and across seasons, reached low μg/L concentrations. Data collected from this research effort indicate contamination with antipsychotic pharmaceuticals, with the potential to adversely impact exposed organisms.
大多数药物在水生系统中以痕量浓度存在，但它们的持续释放和潜在积累可能导致暴露于其中的生物体产生不良健康影响。浓度会随时间发生变化，这是由受纳水体的排放变化、对沉积物的吸附以及其他生物和非生物交换过程驱动的。这项研究的主要目的是更好地了解寒冷气候、河流环境中药物的存在、趋势和动态。为此，在加拿大萨斯喀彻温省的两条污水处理厂（WWTP）的上游和下游，分别在南萨斯喀彻温河和瓦斯卡纳溪，横跨三个季节，测量了一套七种代表性的抗精神病药物。分析物的浓度在 ng/L 范围内，与上游相比，两个 WWTP 的下游浓度通常更高。一些化合物，包括三环类抗抑郁药阿米替林，它是两个地点和所有季节水中和沉积物中最丰富的分析物，达到了低 μg/L 浓度。从这项研究工作中收集的数据表明存在抗精神病药物污染，这有可能对暴露于其中的生物体产生不利影响。
