Du Kaicheng, Zhang Zhiqi, Jing Di, Wang Yumeng, Li Xingyao, Meng Dali
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Phytochemistry. 2022 Nov;203:113382. doi: 10.1016/j.phytochem.2022.113382. Epub 2022 Aug 22.
The phytochemical study on Euphorbia fischeriana, a folk medicinal plant in China, led to the isolation of eight undescribed glycosides, including two diterpene glycosides, three acetophenone glycosides and three tannins together with eight known ones. Their planar structures were elucidated by extensive analyses of 1D, 2D NMR experiments and HRESIMS. The absolute configurations were determined by NOESY experiments, ECD calculations. All undescribed compounds were evaluated for their cytotoxicity and antibacterial activities in vitro. Two diterpene glycosides (1-2) showed cytotoxic activity with IC values ranging from 5.4 to 16.2 μM toward Hep-G2, Hep-3B, A549, NCI-H460 and AGS cells. Tannins (6-8) showed the significant antibacterial activity with MIC values in the range of 1.56-6.25 μg/mL.
对中国民间药用植物狼毒大戟进行的植物化学研究，分离出了8种未描述的糖苷，包括2种二萜糖苷、3种苯乙酮糖苷和3种单宁，以及8种已知化合物。通过对一维、二维核磁共振实验和高分辨电喷雾电离质谱的广泛分析阐明了它们的平面结构。通过核Overhauser效应光谱实验、电子圆二色计算确定了绝对构型。对所有未描述的化合物进行了体外细胞毒性和抗菌活性评估。两种二萜糖苷（1 - 2）对Hep - G2、Hep - 3B、A549、NCI - H460和AGS细胞显示出细胞毒性活性，IC值范围为5.4至16.2 μM。单宁（6 - 8）显示出显著的抗菌活性，最低抑菌浓度值在1.56 - 6.25 μg/mL范围内。
