Department of Translational Research of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Autoimmun Rev. 2022 Nov;21(11):103183. doi: 10.1016/j.autrev.2022.103183. Epub 2022 Aug 23.
Since the beginning of the pandemic, numerous risk factors have been associated with SARS-CoV-2 infection and COVID-19 outcomes, such as older age, male sex, and the presence of comorbidities, such as hypertension, obesity, and diabetes. Preliminary data also suggest epidemiological association between SARS-CoV-2 infection and systemic autoimmune disease. For this reason, we investigated if patients affected by autoimmune thyroid disorders (AITD) are at risk of developing SARS-CoV-2 infection or COVID-19 disease. From April to September 2020, we have conducted a telephone survey that included 515 consecutive unselected patients with known thyroid disorders, of which 350 were affected by AITD. All 11 definitive diagnosis of COVID-19 (def-sympt-COVID-19) belonged to the AITD group, while the rest 14 cases highly suspected for COVID-19 (suspect-sympt-COVID-19) were equally detected in both group (7 in AITD and 7 in not-AITD). The overall prevalence of symptomatic COVID-19 (def-sympt-COVID-19 + suspect-sympt-COVID-19), recorded in the 350 AITD population was statistically significant higher compared to that reported in the Italian and Tuscan general population at the same time period of the present survey (18/350 = 5.14% vs 516/100000 = 0.51% [p < 0.001; OR = 10.45, 95% CI 6.45-16.92] and vs 394/100000 = 0.39% [p < 0.001; OR = 13.70, 95% CI 8.44-22.25], respectively). Therefore, our results suggest a higher prevalence of SARS-CoV-2 infection and COVID-19 disease in patients with AITD.
自疫情大流行开始以来，许多因素都与 SARS-CoV-2 感染和 COVID-19 结局相关，例如年龄较大、男性以及存在高血压、肥胖和糖尿病等合并症。初步数据还表明，SARS-CoV-2 感染与系统性自身免疫性疾病之间存在流行病学关联。因此，我们研究了自身免疫性甲状腺疾病 (AITD) 患者是否有感染 SARS-CoV-2 或患 COVID-19 疾病的风险。2020 年 4 月至 9 月，我们进行了一项电话调查，共纳入了 515 例连续的未经选择的已知甲状腺疾病患者，其中 350 例患有 AITD。所有 11 例 COVID-19 确诊病例（确诊症状性 COVID-19，def-sympt-COVID-19）均来自 AITD 组，而其余 14 例高度疑似 COVID-19 患者（疑似症状性 COVID-19，suspect-sympt-COVID-19）在两组中均有发现（7 例 AITD 和 7 例非 AITD）。在 350 例 AITD 患者中，记录到有症状 COVID-19（确诊症状性 COVID-19+疑似症状性 COVID-19）的总体患病率与同期意大利和托斯卡纳普通人群相比具有统计学意义上的显著升高（18/350=5.14% vs 516/100000=0.51%[p<0.001；比值比 OR=10.45，95%置信区间 6.45-16.92]和 394/100000=0.39%[p<0.001；OR=13.70，95%置信区间 8.44-22.25]）。因此，我们的结果表明，AITD 患者 SARS-CoV-2 感染和 COVID-19 疾病的患病率更高。
