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肥胖合并糖尿病患者的初级减重手术应用。来自糖尿病合作登记处的见解。

Use of primary bariatric surgery among patients with obesity and diabetes. Insights from the Diabetes Collaborative Registry.

机构信息

Saint Luke's Mid America Heart Institute and University of Missouri-Kansas City, Kansas City, MO, USA.

Emory School of Medicine and Rollins School of Public Health, Atlanta, GA, USA.

出版信息

Int J Obes (Lond). 2022 Dec;46(12):2163-2167. doi: 10.1038/s41366-022-01217-w. Epub 2022 Aug 25.

Abstract

Despite its cardiometabolic benefits, bariatric surgery has historically been underused in patients with obesity and diabetes, but contemporary data are lacking. Among 1,520,182 patients evaluated from 2013 to 2019 within a multicenter, longitudinal, US registry of outpatients with diabetes, we found that 462,033 (30%) met eligibility for bariatric surgery. After a median follow-up of 854 days, 6310/384,859 patients (1.6%) underwent primary bariatric surgery, with a slight increase over time (0.38% per year [2013] to 0.68% per year [2018]). Patients who underwent bariatric surgery were more likely to be female (63% vs. 56%), white (87% vs. 82%), have higher body mass indices (42.1 ± 6.9 vs. 40.6 ± 5.9 kg/m), and depression (23% vs. 14%; p < 0.001 for all). Over a median (IQR) follow-up after surgery of 722 days (364-993), patients who underwent bariatric surgery had lost an average of 11.8 ± 18.5 kg (23% of excess body weight), 10.2% were on fewer glucose-lowering medications, and 8.4% were on fewer antihypertensives. Despite bariatric surgery being safer and more accessible over the past two decades, less than one in fifty eligible patients with diabetes receive this therapy.

摘要

尽管减重手术对代谢和心血管有益,但在肥胖和糖尿病患者中的应用一直不足,而目前缺乏相关数据。我们对 2013 年至 2019 年期间在一个包含糖尿病门诊患者的多中心、纵向、美国注册中心的 1520182 例患者进行了评估,发现其中 462033 例(30%)符合减重手术的条件。在中位随访 854 天后,384859 例患者中有 6310 例(1.6%)接受了原发性减重手术,而且这一比例随时间推移略有增加(每年 0.38%[2013 年]至每年 0.68%[2018 年])。接受减重手术的患者更可能为女性(63% vs. 56%)、白人(87% vs. 82%)、体重指数更高(42.1 ± 6.9 vs. 40.6 ± 5.9 kg/m)以及患有抑郁症(23% vs. 14%;所有 P 值均<0.001)。在手术后中位(IQR)随访 722 天(364-993)后,接受减重手术的患者平均体重减轻了 11.8 ± 18.5 公斤(超重体重的 23%),减少使用降血糖药物的患者比例为 10.2%,减少使用降压药的患者比例为 8.4%。尽管在过去二十年中减重手术的安全性和可及性有所提高,但仍不足五分之一符合条件的糖尿病患者接受这种治疗。

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