PPAR 能控制镉吗？
Can PPAR Keep Cadmium in Check?
机构信息
Department of Internal Medicine, Division of Allergy and Immunology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
出版信息
Biomolecules. 2022 Aug 9;12(8):1094. doi: 10.3390/biom12081094.
Abstract
Cd, a naturally occurring endocrine toxin found in tobacco leaves, originates in the environment and enters the body through inhalation, targeting the lungs and kidneys. A study published by Larsen-Carey et al. revealed that cadmium mediates the persistence of classically activated lung macrophages to exacerbate lung injury. The research discovered a novel role for PPAR as an effective regulator for the alternative activation of macrophages in response to Cd and Cd-induced lung injury.
摘要
镉（Cd）是一种存在于烟草叶中的天然内分泌毒素，来源于环境，通过吸入进入人体，主要侵害肺和肾。拉森-凯里等人发表的一项研究表明，镉介导经典激活的肺巨噬细胞持续存在，从而加重肺损伤。该研究发现了 PPAR 的一个新作用，即作为一种有效调节剂，调节巨噬细胞对 Cd 及 Cd 诱导的肺损伤的另一种激活方式。
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