Department of Internal Medicine, Division of Allergy and Immunology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Biomolecules. 2022 Aug 9;12(8):1094. doi: 10.3390/biom12081094.
Cd, a naturally occurring endocrine toxin found in tobacco leaves, originates in the environment and enters the body through inhalation, targeting the lungs and kidneys. A study published by Larsen-Carey et al. revealed that cadmium mediates the persistence of classically activated lung macrophages to exacerbate lung injury. The research discovered a novel role for PPAR as an effective regulator for the alternative activation of macrophages in response to Cd and Cd-induced lung injury.
镉（Cd）是一种存在于烟草叶中的天然内分泌毒素，来源于环境，通过吸入进入人体，主要侵害肺和肾。拉森-凯里等人发表的一项研究表明，镉介导经典激活的肺巨噬细胞持续存在，从而加重肺损伤。该研究发现了 PPAR 的一个新作用，即作为一种有效调节剂，调节巨噬细胞对 Cd 及 Cd 诱导的肺损伤的另一种激活方式。
