De Luca Rosaria, Bonanno Mirjam, Vermiglio Giuliana, Trombetta Giovanni, Andidero Ersilia, Caminiti Angelo, Pollicino Patrizia, Rifici Carmela, Calabrò Rocco Salvatore
IRCCS Centro Neurolesi Bonino Pulejo, Via Palermo, SS 113, C. da Casazza, 98124 Messina, Italy.
Brain Sci. 2022 Aug 6;12(8):1045. doi: 10.3390/brainsci12081045.
Background: Music stimulation is considered a valuable form of intervention in disorders of consciousness (DoC); for instance, verticalization may improve motor and cognitive recovery. Our purpose is to investigate the effects of a novel rehabilitative approach combining robotic verticalization training (RVT) with personalized music stimulation in people with DoC. Methods: Sixteen subjects affected by minimally conscious state due to traumatic brain lesions who attended our Intensive Neuro-Rehabilitation Unit were enrolled in this randomized trial. They received either music robotic verticalization (MRV) using the Erigo device plus a personalized music playlist or only RVT without music stimuli. Each treatment was performed 2 times a week for 8 consecutive weeks in addition to standard neurorehabilitation. Results: We found significant improvements in all patients’ outcomes in the experimental group (who received MRV): Coma Recovery Scale-Revised (CRS-R) (p < 0.01), Level of Cognitive Functioning (LCF) (p < 0.02), Functional Independence Measure (FIM) (p < 0.03), Functional Communication Scale (FCS) (p < 0.007), Trunk Control Test (TCT) (p = 0.05). Significant differences between the two groups were also found in the main outcome measure CRS-R (p < 0.01) but not for TCT and FIM. Conclusions: Our study supports the safety and effectiveness of RVT with the Erigo device in chronic MCS, and the achievement of better outcomes when RVT is combined with music stimulation.
音乐刺激被认为是意识障碍（DoC）干预的一种有价值的形式；例如，身体竖直化可能会改善运动和认知功能的恢复。我们的目的是研究一种将机器人辅助身体竖直化训练（RVT）与个性化音乐刺激相结合的新型康复方法对意识障碍患者的影响。方法：本随机试验纳入了16名因创伤性脑损伤而处于最低意识状态并在我们的强化神经康复单元接受治疗的患者。他们要么接受使用Erigo设备加个性化音乐播放列表的音乐机器人辅助身体竖直化训练（MRV），要么只接受无音乐刺激的RVT。除标准神经康复治疗外，每种治疗每周进行2次，连续进行8周。结果：我们发现实验组（接受MRV治疗的患者）所有患者的各项指标均有显著改善：昏迷恢复量表修订版（CRS-R）（p < 0.01）、认知功能水平（LCF）（p < 0.02）、功能独立性测量（FIM）（p < 0.03）、功能沟通量表（FCS）（p < 0.007）、躯干控制测试（TCT）（p = 0.05）。在主要结局指标CRS-R上两组也存在显著差异（p < 0.01），但TCT和FIM不存在显著差异。结论：我们的研究支持在慢性最低意识状态下使用Erigo设备进行RVT的安全性和有效性，以及RVT与音乐刺激相结合能取得更好的治疗效果。
