Almasabi Faris, van Zwieten Gusta, Alosaimi Faisal, Smit Jasper V, Temel Yasin, Janssen Marcus L F, Jahanshahi Ali
Department of Neurosurgery, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands.
School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6229 ER Maastricht, The Netherlands.
Brain Sci. 2022 Aug 18;12(8):1099. doi: 10.3390/brainsci12081099.
Tinnitus is defined as the phantom perception of sound. To date, there is no curative treatment, and contemporary treatments have failed to show beneficial outcomes. Deep brain stimulation has been suggested as a potential therapy for refractory tinnitus. However, the optimal target and stimulation regimens remain to be defined. Herein, we investigated metabolic and neuronal activity changes using cytochrome C oxidase histochemistry and c-Fos immunohistochemistry in a noise trauma-induced rat model of tinnitus. We also assessed changes in neuronal activity following medial geniculate body (MGB) high-frequency stimulation (HFS). Metabolic activity was reduced in the primary auditory cortex, MGB and CA1 region of the hippocampus in noise-exposed rats. Additionally, c-Fos expression was increased in the primary auditory cortex of those animals. Furthermore, MGB-HFS enhanced c-Fos expression in the thalamic reticular nucleus. We concluded that noise trauma alters tissue activity in multiple brain areas including the auditory and limbic regions. MGB-HFS resulted in higher neuronal activity in the thalamic reticular nucleus. Given the prominent role of the auditory thalamus in tinnitus, these data provide more rationales towards targeting the MGB with HFS as a symptom management tool in tinnitus.
耳鸣被定义为对声音的幻听。迄今为止，尚无治愈性治疗方法，且当代治疗方法未能显示出有益效果。深部脑刺激已被提议作为难治性耳鸣的一种潜在治疗方法。然而，最佳靶点和刺激方案仍有待确定。在此，我们使用细胞色素C氧化酶组织化学和c-Fos免疫组织化学，在噪声创伤诱导的耳鸣大鼠模型中研究了代谢和神经元活动变化。我们还评估了内侧膝状体（MGB）高频刺激（HFS）后神经元活动的变化。噪声暴露大鼠的初级听觉皮层、MGB和海马CA1区的代谢活动降低。此外，这些动物的初级听觉皮层中c-Fos表达增加。此外，MGB-HFS增强了丘脑网状核中的c-Fos表达。我们得出结论，噪声创伤会改变包括听觉和边缘区域在内的多个脑区的组织活动。MGB-HFS导致丘脑网状核中的神经元活动增加。鉴于听觉丘脑在耳鸣中的突出作用，这些数据为将MGB作为耳鸣症状管理工具进行HFS靶向治疗提供了更多理论依据。
