Florido Javier, Rodriguez-Santana César, Martinez-Ruiz Laura, López-Rodríguez Alba, Acuña-Castroviejo Darío, Rusanova Iryna, Escames Germaine
Biomedical Research Center, Health Sciences Technology Park, University of Granada, 18016 Granada, Spain.
Department of Physiology, Faculty of Medicine, University of Granada, 18016 Granada, Spain.
Antioxidants (Basel). 2022 Aug 20;11(8):1621. doi: 10.3390/antiox11081621.
Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have evolved as regulators of important signaling pathways. In this context, tumor cells have an altered redox balance compared to normal cells, which can be targeted as an antitumoral therapy by ROS levels and by decreasing the capacity of the antioxidant system, leading to programmed cell death. Melatonin is of particular importance in the development of innovative cancer treatments due to its oncostatic impact and lack of adverse effects. Despite being widely recognized as a pro-oxidant molecule in tumor cells, the mechanism of action of melatonin remains unclear, which has hindered its use in clinical treatments. The current review aims to describe and clarify the proposed mechanism of action of melatonin inducing ROS production in cancer cells in order to propose future anti-neoplastic clinical applications.
活性氧（ROS）是一类高反应性分子，已演变为重要信号通路的调节因子。在这种情况下，与正常细胞相比，肿瘤细胞的氧化还原平衡发生了改变，可通过调节ROS水平和降低抗氧化系统的能力将其作为抗肿瘤治疗的靶点，从而导致程序性细胞死亡。褪黑素因其抗癌作用和缺乏副作用，在创新癌症治疗的发展中具有特别重要的意义。尽管褪黑素在肿瘤细胞中被广泛认为是一种促氧化分子，但其作用机制仍不清楚，这阻碍了其在临床治疗中的应用。本综述旨在描述和阐明褪黑素诱导癌细胞产生ROS的作用机制，以便提出未来的抗肿瘤临床应用。
