Zhang Bingchang, Huang Yan, Huang Yong
State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning 530021, China.
Nanomaterials (Basel). 2024 Apr 8;14(7):648. doi: 10.3390/nano14070648.
Nanodynamic therapy (NDT) exerts its anti-tumor effect by activating nanosensitizers to generate large amounts of reactive oxygen species (ROS) in tumor cells. NDT enhances tumor-specific targeting and selectivity by leveraging the tumor microenvironment (TME) and mechanisms that boost anti-tumor immune responses. It also minimizes damage to surrounding healthy tissues and enhances cytotoxicity in tumor cells, showing promise in cancer treatment, with significant potential. This review covers the research progress in five major nanodynamic therapies: photodynamic therapy (PDT), electrodynamic therapy (EDT), sonodynamic therapy (SDT), radiodynamic therapy (RDT), and chemodynamic therapy (CDT), emphasizing the significant role of advanced nanotechnology in the development of NDT for anti-tumor purposes. The mechanisms, effects, and challenges faced by these NDTs are discussed, along with their respective solutions for enhancing anti-tumor efficacy, such as pH response, oxygen delivery, and combined immunotherapy. Finally, this review briefly addresses challenges in the clinical translation of NDT.
纳米动力疗法（NDT）通过激活纳米敏化剂在肿瘤细胞中产生大量活性氧（ROS）来发挥其抗肿瘤作用。NDT通过利用肿瘤微环境（TME）和增强抗肿瘤免疫反应的机制，提高肿瘤特异性靶向性和选择性。它还将对周围健康组织的损伤降至最低，并增强肿瘤细胞的细胞毒性，在癌症治疗中显示出前景，具有巨大潜力。本综述涵盖了五种主要纳米动力疗法的研究进展：光动力疗法（PDT）、电动力疗法（EDT）、声动力疗法（SDT）、放射动力疗法（RDT）和化学动力疗法（CDT），强调了先进纳米技术在开发用于抗肿瘤目的的NDT中的重要作用。讨论了这些NDT的机制、效果和面临的挑战，以及它们各自提高抗肿瘤疗效的解决方案，如pH响应、氧气输送和联合免疫疗法。最后，本综述简要阐述了NDT临床转化中面临的挑战。
