Zelini Paola, d'Angelo Piera, Cereda Emanuele, Klersy Catherine, Sabrina Peressini, Albertini Riccardo, Grugnetti Giuseppina, Grugnetti Anna Maria, Marena Carlo, Cutti Sara, Lilleri Daniele, Cassaniti Irene, Fausto Baldanti, Caccialanza Riccardo
Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
Department of Obstetrics and Gynecology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy.
Biomedicines. 2022 Aug 17;10(8):1993. doi: 10.3390/biomedicines10081993.
The use of micronutrients such as vitamin D could improve the response to viral vaccines, particularly in immunosuppressed and immunosenescent subjects. Here, we analysed the association between serum 25-hydroxyvitamin D (25OHD) levels and the immune response elicited by the BNT162b2 vaccine in a cohort of 101 healthcare workers naïve for SARS-CoV-2 infection. We observed no significant differences in anti-spike (S) IgG and T-cell responses according to the 25OHD status at baseline. However, significant correlations between the 25OHD concentration at baseline and (i) the anti-S response (p < 0.020) and (ii) the neutralizing antibody (NT) titre (p = 0.040) at six months after the second dose were detected. We concluded that adequate levels of vitamin D may improve the immune response to mRNA vaccines such as BNT162b2, and that further larger studies are warranted in order to confirm these preliminary observations.
使用维生素D等微量营养素可以改善对病毒疫苗的反应，特别是在免疫抑制和免疫衰老的个体中。在此，我们分析了101名未感染过SARS-CoV-2的医护人员队列中血清25-羟基维生素D（25OHD）水平与BNT162b2疫苗引发的免疫反应之间的关联。根据基线时的25OHD状态，我们未观察到抗刺突（S）IgG和T细胞反应有显著差异。然而，在第二次接种后六个月时，检测到基线时的25OHD浓度与（i）抗S反应（p < 0.020）和（ii）中和抗体（NT）滴度（p = 0.040）之间存在显著相关性。我们得出结论，充足的维生素D水平可能会改善对BNT162b2等mRNA疫苗的免疫反应，并且有必要进行进一步的大规模研究以证实这些初步观察结果。
