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肥胖患者外周血细胞中 、 和 的mRNA水平升高，且可能预示着严重的COVID-19病情进展。

Increased mRNA Levels of , , and in Peripheral Blood Cells Are Present in Patients with Obesity and May Predict Severe COVID-19 Evolution.

作者信息

Pomar Catalina A, Bonet M Luisa, Ferre-Beltrán Adrián, Fraile-Ribot Pablo A, García-Gasalla Mercedes, Riera Melchor, Picó Catalina, Palou Andreu

机构信息

Laboratory of Molecular Biology, Nutrition and Biotechnology, Group of Nutrigenomics, Biomarkers and Risk Evaluation, University of the Balearic Islands, 07122 Palma, Spain.

Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma, Spain.

出版信息

Biomedicines. 2022 Aug 18;10(8):2007. doi: 10.3390/biomedicines10082007.

DOI:10.3390/biomedicines10082007
PMID:36009555
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9406212/
Abstract

Gene expression patterns in blood cells from SARS-CoV-2 infected individuals with different clinical phenotypes and body mass index (BMI) could help to identify possible early prognosis factors for COVID-19. We recruited patients with COVID-19 admitted in Hospital Universitari Son Espases (HUSE) between March 2020 and November 2021, and control subjects. Peripheral blood cells (PBCs) and plasma samples were obtained on hospital admission. Gene expression of candidate transcriptomic biomarkers in PBCs were compared based on the patients’ clinical status (mild, severe and critical) and BMI range (normal weight, overweight, and obesity). mRNA levels of ADAM17, IFITM3, IL6, CXCL10, CXCL11, IFNG and TYK2 were increased in PBCs of COVID-19 patients (n = 73) compared with controls (n = 47), independently of sex. Increased expression of IFNE was observed in the male patients only. PBC mRNA levels of ADAM17, IFITM3, CXCL11, and CCR2 were higher in those patients that experienced a more serious evolution during hospitalization. ADAM17, IFITM3, IL6 and IFNE were more highly expressed in PBCs of patients with obesity. Interestingly, the expression pattern of ADAM17, IFITM3 and IFNE in PBCs was related to both the severity of COVID-19 evolution and obesity status, especially in the male patients. In conclusion, gene expression in PBCs can be useful for the prognosis of COVID-19 evolution.

摘要

2019冠状病毒病（COVID-19）感染个体血细胞中的基因表达模式，这些个体具有不同的临床表型和体重指数（BMI），这可能有助于识别COVID-19可能的早期预后因素。我们招募了2020年3月至2021年11月期间在Son Espases大学医院（HUSE）住院的COVID-19患者以及对照受试者。入院时采集外周血细胞（PBC）和血浆样本。根据患者的临床状态（轻度、重度和危重症）和BMI范围（正常体重、超重和肥胖），比较PBC中候选转录组生物标志物的基因表达。与对照组（n = 47）相比，COVID-19患者（n = 73）的PBC中ADAM17、IFITM3、IL6、CXCL10、CXCL11、IFNG和TYK2的mRNA水平升高，与性别无关。仅在男性患者中观察到IFNE表达增加。在住院期间病情进展更严重的患者中，ADAM17、IFITM3、CXCL11和CCR2的PBC mRNA水平更高。ADAM17、IFITM3、IL6和IFNE在肥胖患者的PBC中表达更高。有趣的是，PBC中ADAM17、IFITM3和IFNE的表达模式与COVID-19病情的严重程度和肥胖状态均相关，尤其是在男性患者中。总之，PBC中的基因表达可用于COVID-19病情的预后判断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1986/9406212/ee922f4a6338/biomedicines-10-02007-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1986/9406212/c4fda95aad9b/biomedicines-10-02007-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1986/9406212/7750669aefd4/biomedicines-10-02007-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1986/9406212/ed5710e7851d/biomedicines-10-02007-g003.jpg
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