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The influence of IFITM3 polymorphisms on susceptibility to SARS-CoV-2 infection and severity of COVID-19.IFITM3 多态性对 SARS-CoV-2 感染易感性和 COVID-19 严重程度的影响。
Cytokine. 2021 Jun;142:155492. doi: 10.1016/j.cyto.2021.155492. Epub 2021 Mar 6.
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Impact of interferon-induced transmembrane protein 3 gene rs12252 polymorphism on COVID-19 mortality.干扰素诱导跨膜蛋白 3 基因 rs12252 多态性对 COVID-19 死亡率的影响。
Cytokine. 2022 Sep;157:155957. doi: 10.1016/j.cyto.2022.155957. Epub 2022 Jul 2.
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Interferon-Induced Transmembrane Protein-3 Rs12252-G Variant Increases COVID-19 Mortality Potential in Egyptian Population.干扰素诱导跨膜蛋白 3 的 rs12252-G 变异增加了埃及人群 COVID-19 的死亡风险。
Viral Immunol. 2024 May;37(4):186-193. doi: 10.1089/vim.2024.0015.
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The significance of IFITM3 polymorphism in COVID-19 asymptomatic and ICU admission Kurdish patients.IFITM3 多态性在 COVID-19 无症状和 ICU 入住库尔德患者中的意义。
Cytokine. 2023 Nov;171:156349. doi: 10.1016/j.cyto.2023.156349. Epub 2023 Sep 6.
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IFITM3 Inhibits SARS-CoV-2 Infection and Is Associated with COVID-19 Susceptibility.IFITM3 抑制 SARS-CoV-2 感染，并与 COVID-19 易感性相关。
Viruses. 2022 Nov 18;14(11):2553. doi: 10.3390/v14112553.
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Ethnic variation in risk genotypes based on single nucleotide polymorphisms (SNPs) of the interferon-inducible transmembrane 3 (IFITM3) gene, a susceptibility factor for pandemic 2009 H1N1 influenza A virus.干扰素诱导跨膜蛋白 3（IFITM3）基因单核苷酸多态性（SNPs）与大流行 2009 年 H1N1 流感病毒易感性相关的风险基因型的种族差异。
Immunogenetics. 2020 Dec;72(9-10):447-453. doi: 10.1007/s00251-020-01188-0. Epub 2020 Nov 10.
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Population genetics of IFITM3 in Portugal and Central Africa reveals a potential modifier of influenza severity.葡萄牙和中非的 IFITM3 群体遗传学研究揭示了流感严重程度的一个潜在修饰因子。
Immunogenetics. 2018 Mar;70(3):169-177. doi: 10.1007/s00251-017-1026-2. Epub 2017 Aug 25.
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Association between the interferon-induced transmembrane protein 3 gene () rs34481144 / rs12252 haplotypes and COVID-19.干扰素诱导跨膜蛋白3基因（）rs34481144 / rs12252单倍型与2019冠状病毒病的关联。
Curr Res Virol Sci. 2021;2:100016. doi: 10.1016/j.crviro.2021.100016. Epub 2021 Nov 29.
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TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among severe COVID-19 ICU patients in Morocco.摩洛哥重症 COVID-19 ICU 患者中 TYK2、IFITM3、IFNAR2 和 OAS3 单核苷酸多态性。
Int J Immunopathol Pharmacol. 2024 Jan-Dec;38:3946320241257241. doi: 10.1177/03946320241257241.
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Interferon-induced transmembrane protein 3 gene polymorphisms are associated with COVID-19 susceptibility and severity: A meta-analysis.干扰素诱导跨膜蛋白 3 基因多态性与 COVID-19 易感性和严重程度相关：一项荟萃分析。
J Infect. 2022 Jun;84(6):825-833. doi: 10.1016/j.jinf.2022.04.029. Epub 2022 Apr 21.
引用本文的文献
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Attenuation of IFITM proteins' antiviral activity through sequestration into intraluminal vesicles of late endosomes.通过隔离到晚期内体的腔内小泡中减弱IFITM蛋白的抗病毒活性。
Front Immunol. 2025 Aug 21;16:1647166. doi: 10.3389/fimmu.2025.1647166. eCollection 2025.
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Genetic variants in influence SARS-CoV-2 infection susceptibility within Mexican Mestizos.基因变异影响墨西哥梅斯蒂索人对新冠病毒的感染易感性。
Front Genet. 2025 Apr 14;16:1558189. doi: 10.3389/fgene.2025.1558189. eCollection 2025.
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Genetic Predictors of Paxlovid Treatment Response: The Role of IFNAR2, OAS1, OAS3, and ACE2 in COVID-19 Clinical Course.帕罗韦德治疗反应的基因预测指标：IFNAR2、OAS1、OAS3和ACE2在新冠临床病程中的作用
J Pers Med. 2025 Apr 17;15(4):156. doi: 10.3390/jpm15040156.
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Exploring Clinical and Imaging Differences in COVID-19: an Observational Approach to the IFITM3 rs12252 Polymorphism.探索新型冠状病毒肺炎的临床和影像学差异：对干扰素诱导跨膜蛋白3基因（IFITM3）rs12252多态性的观察性研究
Int J Gen Med. 2025 Apr 10;18:2077-2091. doi: 10.2147/IJGM.S512160. eCollection 2025.
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Impact of single nucleotide polymorphism of IL-27P28 rs153109 and IFITM3 rs12252 on susceptibility and severity of COVID-19 in Egyptian patients: a case control study.白细胞介素-27P28 rs153109单核苷酸多态性和干扰素诱导跨膜蛋白3 rs12252对埃及患者感染新型冠状病毒肺炎易感性及严重程度的影响：一项病例对照研究
Virol J. 2025 Mar 8;22(1):66. doi: 10.1186/s12985-025-02668-z.
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TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among severe COVID-19 ICU patients in Morocco.摩洛哥重症 COVID-19 ICU 患者中 TYK2、IFITM3、IFNAR2 和 OAS3 单核苷酸多态性。
Int J Immunopathol Pharmacol. 2024 Jan-Dec;38:3946320241257241. doi: 10.1177/03946320241257241.
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Next-generation sequencing of host genetics risk factors associated with COVID-19 severity and long-COVID in Colombian population.哥伦比亚人群中与 COVID-19 严重程度和长新冠相关的宿主遗传学风险因素的下一代测序。
Sci Rep. 2024 Apr 11;14(1):8497. doi: 10.1038/s41598-024-57982-3.
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Association of genetic polymorphisms with COVID-19 infection and outcomes: An updated meta-analysis based on 62 studies.基因多态性与新型冠状病毒肺炎感染及预后的关联：基于62项研究的最新荟萃分析
Heliyon. 2023 Dec 14;10(1):e23662. doi: 10.1016/j.heliyon.2023.e23662. eCollection 2024 Jan 15.
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Influence of the Single Nucleotide Polymorphisms rs12252 and rs34481144 in on the Antibody Response after Vaccination against COVID-19.rs12252和rs34481144单核苷酸多态性对COVID-19疫苗接种后抗体反应的影响。
Vaccines (Basel). 2023 Jul 19;11(7):1257. doi: 10.3390/vaccines11071257.
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Cyclosporines Antagonize the Antiviral Activity of IFITMProteins by Redistributing Them toward the Golgi Apparatus.环孢菌素通过将 IFITM 蛋白重分布到高尔基体而拮抗其抗病毒活性。
Biomolecules. 2023 Jun 3;13(6):937. doi: 10.3390/biom13060937.
本文引用的文献
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The frequency of combined IFITM3 haplotype involving the reference alleles of both rs12252 and rs34481144 is in line with COVID-19 standardized mortality ratio of ethnic groups in England.涉及rs12252和rs34481144参考等位基因的IFITM3联合单倍型频率与英格兰各民族的新冠标准化死亡率一致。
PeerJ. 2020 Nov 12;8:e10402. doi: 10.7717/peerj.10402. eCollection 2020.
2
Ethnic variation in risk genotypes based on single nucleotide polymorphisms (SNPs) of the interferon-inducible transmembrane 3 (IFITM3) gene, a susceptibility factor for pandemic 2009 H1N1 influenza A virus.干扰素诱导跨膜蛋白 3（IFITM3）基因单核苷酸多态性（SNPs）与大流行 2009 年 H1N1 流感病毒易感性相关的风险基因型的种族差异。
Immunogenetics. 2020 Dec;72(9-10):447-453. doi: 10.1007/s00251-020-01188-0. Epub 2020 Nov 10.
3
The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19.干扰素诱导跨膜蛋白 3 基因（IFITM3）rs12252 C 变异与 COVID-19 相关。
Cytokine. 2021 Jan;137:155354. doi: 10.1016/j.cyto.2020.155354. Epub 2020 Oct 23.
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Minor Allele of Interferon-Induced Transmembrane Protein 3 Polymorphism (rs12252) Is Covered Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Mortality: A Worldwide Epidemiological Investigation.干扰素诱导跨膜蛋白3多态性（rs12252）的次要等位基因对严重急性呼吸综合征冠状病毒2感染和死亡率具有保护作用：一项全球流行病学调查。
J Infect Dis. 2021 Jan 4;223(1):175-178. doi: 10.1093/infdis/jiaa630.
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Genetic comparison among various coronavirus strains for the identification of potential vaccine targets of SARS-CoV2.对各种冠状病毒株进行遗传比较，以鉴定 SARS-CoV-2 的潜在疫苗靶标。
Infect Genet Evol. 2021 Apr;89:104490. doi: 10.1016/j.meegid.2020.104490. Epub 2020 Aug 1.
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Interferon-Induced Transmembrane Protein 3 Related to Coronavirus Disease 2019.与2019冠状病毒病相关的干扰素诱导跨膜蛋白3
J Infect Dis. 2020 Sep 14;222(8):1413. doi: 10.1093/infdis/jiaa454.
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Interferon-Induced Transmembrane Protein 3 Genetic Variant rs12252-C Associated With Disease Severity in Coronavirus Disease 2019.干扰素诱导跨膜蛋白 3 基因变异 rs12252-C 与 2019 年冠状病毒病疾病严重程度相关。
J Infect Dis. 2020 Jun 16;222(1):34-37. doi: 10.1093/infdis/jiaa224.
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Strong association of regulatory single nucleotide polymorphisms (SNPs) of the IFITM3 gene with influenza H1N1 2009 pandemic virus infection.IFITM3基因调控单核苷酸多态性（SNP）与2009年甲型H1N1流感大流行病毒感染的强关联。
Cell Mol Immunol. 2020 Jun;17(6):662-664. doi: 10.1038/s41423-019-0322-1. Epub 2019 Nov 4.
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Association between rs12252 and influenza susceptibility and severity: an updated meta-analysis.rs12252与流感易感性及严重程度之间的关联：一项更新的荟萃分析。
Epidemiol Infect. 2018 Nov 13;147:e39. doi: 10.1017/S0950268818002832.
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Lack of Truncated IFITM3 Transcripts in Cells Homozygous for the rs12252-C Variant That is Associated With Severe Influenza Infection.在与严重流感感染相关的 rs12252-C 变异纯合的细胞中缺乏截短的 IFITM3 转录本。
J Infect Dis. 2018 Jan 4;217(2):257-262. doi: 10.1093/infdis/jix512.
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