IFITM3 多态性对 SARS-CoV-2 感染易感性和 COVID-19 严重程度的影响。
The influence of IFITM3 polymorphisms on susceptibility to SARS-CoV-2 infection and severity of COVID-19.
机构信息
Department of Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
出版信息
Cytokine. 2021 Jun;142:155492. doi: 10.1016/j.cyto.2021.155492. Epub 2021 Mar 6.
BACKGROUND AND AIMS
The interferon-induced transmembrane protein 3 (IFITM3) plays an important role in the adaptive and innate immune response by inhibiting viral membrane hemifusion between the host and viral cell cytoplasm. Single nucleotide polymorphisms (SNPs) in the gene IFITM3 have been associated with susceptibility and severity of influenza or other viral infections. We aimed to analyze the role of SNPs in the gene IFITM3 in SARS-CoV-2 infection.
METHODS
We performed genotyping of the SNPs rs12252 and rs34481144 in the gene IFITM3 in 239 SARS-CoV-2-positive and 253 SARS-CoV-2-negative patients. We analyzed the association of the SNPs with susceptibility to SARS-CoV-2 infection and severity of COVID-19.
RESULTS
SARS-CoV-2-positive and SARS-CoV-2-negative patients did not differ regarding demographics. Neither IFITM3 rs12252 nor rs34481144 polymorphisms were related to SARS-CoV-2 infection risk or severity of COVID-19. Interestingly, we observed the putative deleterious rs12252 CC genotype only in SARS-CoV-2-positive patients (N = 2). Also, we found a non-significant higher frequency of rs34481144 A-allele carriers in the patients with 'serious' COVID-19.
CONCLUSIONS
In summary, we could not confirm the recently reported influence of polymorphisms in the gene IFITM3 on SARS-CoV-2 infection risk or severity of COVID-19 in a German cohort. Additional studies are needed to clarify the influence of the rs12252 CC genotype on SARS-CoV-2 infection risk and the rs34481144 A-allele on course of COVID-19.
背景和目的
干扰素诱导跨膜蛋白 3（IFITM3）通过抑制宿主与病毒细胞质之间的病毒膜半融合，在适应性和先天免疫反应中发挥重要作用。IFITM3 基因中的单核苷酸多态性（SNP）与流感或其他病毒感染的易感性和严重程度有关。我们旨在分析 IFITM3 基因中的 SNP 在 SARS-CoV-2 感染中的作用。
方法
我们对 239 例 SARS-CoV-2 阳性和 253 例 SARS-CoV-2 阴性患者的 IFITM3 基因中的 SNP rs12252 和 rs34481144 进行了基因分型。我们分析了 SNP 与 SARS-CoV-2 感染易感性和 COVID-19 严重程度的关系。
结果
SARS-CoV-2 阳性和 SARS-CoV-2 阴性患者的人口统计学特征无差异。IFITM3 rs12252 或 rs34481144 多态性均与 SARS-CoV-2 感染风险或 COVID-19 严重程度无关。有趣的是，我们仅在 SARS-CoV-2 阳性患者（N=2）中观察到假定有害的 rs12252 CC 基因型。此外，我们发现“严重”COVID-19 患者中 rs34481144 A-等位基因携带者的频率略高，但无统计学意义。
结论
总之，我们不能在德国队列中证实最近报道的 IFITM3 基因多态性对 SARS-CoV-2 感染风险或 COVID-19 严重程度的影响。需要进一步研究来阐明 rs12252 CC 基因型对 SARS-CoV-2 感染风险的影响和 rs34481144 A-等位基因对 COVID-19 病程的影响。
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