de Rojas Itziar, Hernández Isabel, Montrreal Laura, Quintela Inés, Calero Miguel, Royo Jose Luís, Huerto Vilas Raquel, González-Pérez Antonio, Franco-Macías Emilio, Macías Juan, Menéndez-González Manuel, Frank-García Ana, Diez-Fairen Mónica, Lage Carmen, García-Madrona Sebastián, Aguilera Nuria, García-González Pablo, Puerta Raquel, Sotolongo-Grau Oscar, Alonso-Lana Silvia, Rábano Alberto, Arias Pastor Alfonso, Pastor Ana Belén, Corma-Gómez Anaïs, Martín Montes Angel, Martínez Rodríguez Carmen, Buiza-Rueda Dolores, Periñán Maria Teresa, Rodriguez-Rodriguez Eloy, Alvarez Ignacio, Rosas Allende Irene, Pineda Juan A, Bernal Sánchez-Arjona María, Fernández-Fuertes Marta, Mendoza Silvia, Del Ser Teodoro, Garcia-Ribas Guillermo, Sánchez-Juan Pascual, Pastor Pau, Bullido María J, Álvarez Victoria, Real Luis M, Mir Pablo, Piñol-Ripoll Gerard, García-Alberca Jose María, Medina Miguel, Orellana Adelina, Butler Chris R, Marquié Marta, Sáez María Eugenia, Carracedo Ángel, Tárraga Lluís, Boada Mercè, Ruiz Agustín
Research Center and Memory Clinic, Ace Alzheimer Center Barcelona-Universitat Internacional de Catalunya, 08017 Barcelona, Spain.
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain.
J Pers Med. 2021 Dec 7;11(12):1318. doi: 10.3390/jpm11121318.
Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region () implicated in the susceptibility to SARS-CoV-2 infection and gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis.
新兴研究表明，几个染色体区域可能是参与新冠病毒感染易感性和疾病转归的宿主遗传因素。我们利用GR@ACE/DEGESCO研究开展了一项新冠病毒全基因组关联研究，寻找与新冠疾病相关的易感性因素。为此，我们将221例新冠确诊病例与17035例新冠疾病状态未知的个体进行了比较。然后，我们对来自新冠病毒宿主遗传学倡议组织的公开数据进行了荟萃分析。由于该位点被认为是新冠疾病的一个潜在修饰因子，我们增加了按痴呆状态或疾病严重程度分层的敏感性分析。我们证实了3p21.31区域（）的存在与新冠病毒感染易感性有关，且基因可能与新冠疾病严重程度有关。然而，在新冠死亡结局或该位点的分层分析（仅痴呆和非痴呆分层）中未观察到统计学上显著的关联，这并不支持其参与新冠病毒病理生物学或新冠疾病预后。
