Arenales Arauz Y Laurisa, Ahuja Gargi, Kamsma Ype P T, Kortholt Arjan, van der Zee Eddy A, van Heuvelen Marieke J G
Department of Human Movement Sciences, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands.
Molecular Neurobiology, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, 9747 AG Groningen, The Netherlands.
Biology (Basel). 2022 Aug 19;11(8):1238. doi: 10.3390/biology11081238.
(1) Background: When the severity of Parkinson's Disease (PD) increases, patients often have difficulties in performing exercises. Whole-Body Vibration (WBV) may be a suitable alternative. This systematic review aims to clarify if WBV shows potential as rehabilitative therapy for PD patients. (2) Methods: We searched several databases for controlled trials investigating the effects of WBV (1) on PD populations and (2) PD neuropathological mechanisms. We included both human and animal studies and performed meta-analyses. (3) Results: The studies on PD populations (14 studies) show an overall significant, but small, effect in favor of WBV (Hedges' g = 0.28), for which the effects on stability (Hedges' g = 0.39) and balance (Hedges' g = 0.30) are the most prominent. The studies on the neuropathological mechanisms (18 studies) show WBV effects on neuroinflammation (Hedges' g = -1.12) and several specific WBV effects on neurotransmitter systems, growth factors, neurogenesis, synaptic plasticity and oxidative stress. (4) Conclusions: The effects of WBV on human PD patients remains inconclusive. Nevertheless, WBV protocols with sufficient duration (≥3 weeks), session frequency (≥3 sessions/week) and vibration frequency (≥20 Hz) show potential as a treatment method, especially for motor function. The potential of WBV for PD patients is confirmed by the effects on the neuropathological mechanisms in mostly non-PD populations. We recommend high-quality future studies on both PD patients and PD mouse models to optimize WBV protocols and to examine the neuropathological mechanisms in PD populations.
（1）背景：帕金森病（PD）病情加重时，患者常难以进行锻炼。全身振动（WBV）可能是一种合适的替代方法。本系统评价旨在明确WBV是否具有作为PD患者康复治疗手段的潜力。（2）方法：我们在多个数据库中检索了关于WBV对（1）PD人群和（2）PD神经病理机制影响的对照试验。我们纳入了人类和动物研究并进行了荟萃分析。（3）结果：关于PD人群的研究（14项研究）显示，总体上有利于WBV的效应显著但较小（Hedges' g = 0.28），其中对稳定性（Hedges' g = 0.39）和平衡（Hedges' g = 0.30）的影响最为突出。关于神经病理机制的研究（18项研究）显示WBV对神经炎症有影响（Hedges' g = -1.12），以及对神经递质系统、生长因子、神经发生、突触可塑性和氧化应激有若干特定的WBV效应。（4）结论：WBV对人类PD患者的影响尚无定论。然而，持续时间足够长（≥3周）、 session频率（≥3次/周）和振动频率（≥20 Hz）的WBV方案显示出作为一种治疗方法的潜力，尤其是对运动功能。WBV对大多非PD人群神经病理机制的影响证实了其对PD患者的潜力。我们建议未来针对PD患者和PD小鼠模型开展高质量研究，以优化WBV方案并研究PD人群的神经病理机制。
