Loumame El Hassan, Tounsi Abdessamad, Amir Soumia, Soraa Nabila, Ouazzani Naaila
Environmental, Ecological and Agro-Industrial Engineering Laboratory, University Sultan Moulay Slimane, Beni-Mellal 23000, Morocco.
Microbiology Laboratory, University Hospital Mohamed VI, Cadi Ayyad University, Marrakech 40000, Morocco.
Antibiotics (Basel). 2022 Aug 15;11(8):1103. doi: 10.3390/antibiotics11081103.
The aim of this work is to identify and count antimicrobial resistance (AMR) in hospital effluents (HEs) of 2 units of the University Hospital Mohamed VI the Mother and Child Hospital (MCH) and the Ar-razi Surgical Hospital (ArzH), and to compare the two hospital units in terms of ARMs and seasonal variation. Each HE was sampled during 2016 and 2017. After identification of the pathogenic strains and determination of AMR, the results were reported for 24 ABs, including 3 carbapenems (CBP), and their consumption rates. The Predicted environmental concentration (PEC) rate of carbapenems in the HE of the study sites is calculated. A comparative analysis of the AMR of the isolated bacterial species was performed and related to the evolution of PEC in HEs. In the ArzH effluents:15 strains isolated, 7 are carbanepenem-resistant Enterobacteria (CRE) and are resistant to at least one of the 3 carbapenems tested. ArzH and MCH effluents respectively show some similarities: 26.87% and 28.57% of isolated bacteria are resistant to ertapenem while 43.48% and 57.14% are resistant to meropenem. However, for imipenem, the MCH effluent has a higher percentage of bacterial antibiotic resistance than ArzH. In addition, the percentage of resistance in each hospital unit effluent is mainly in relation with the increasing antibiotic consumption and predicted environmental values PEC for very antibiotic in each unit in the same period.
这项工作的目的是识别并统计穆罕默德六世大学医院两个科室（母婴医院（MCH）和阿齐兹外科医院（ArzH））医院污水（HEs）中的抗菌药物耐药性（AMR），并在抗菌药物耐药性和季节变化方面比较这两个医院科室。在2016年和2017年期间对每个医院污水进行了采样。在鉴定致病菌株并确定抗菌药物耐药性后，报告了24种抗菌药物的结果，包括3种碳青霉烯类药物（CBP）及其消耗率。计算了研究地点医院污水中碳青霉烯类药物的预测环境浓度（PEC）率。对分离出的细菌物种的抗菌药物耐药性进行了比较分析，并与医院污水中PEC的变化相关联。在阿齐兹外科医院的污水中：分离出15株菌株，7株是耐碳青霉烯肠杆菌（CRE），并且对所测试的3种碳青霉烯类药物中的至少一种耐药。阿齐兹外科医院和母婴医院的污水分别显示出一些相似之处：分离出的细菌中分别有26.87%和28.57%对厄他培南耐药，而43.48%和57.14%对美罗培南耐药。然而，对于亚胺培南，母婴医院污水中细菌抗生素耐药的百分比高于阿齐兹外科医院。此外，每个医院科室污水中的耐药百分比主要与同期每个科室中每种抗生素的抗生素消耗量增加和预测环境值PEC有关。
