Łyżwa Ewa, Siemion-Szcześniak Izabela, Sobiecka Małgorzata, Lewandowska Katarzyna, Zimna Katarzyna, Bartosiewicz Małgorzata, Jakubowska Lilia, Augustynowicz-Kopeć Ewa, Tomkowski Witold
1st Department of Lung Diseases, National Research Institute of Tuberculosis and Lung Diseases, 01-138 Warsaw, Poland.
Department of Radiology, National Research Institute of Tuberculosis and Lung Diseases, 01-138 Warsaw, Poland.
Diagnostics (Basel). 2022 Jul 29;12(8):1826. doi: 10.3390/diagnostics12081826.
is a slow-growing, nontuberculous mycobacterium (NTM) belonging to the (). It was identified as a unique species in 2004. Since 2013 it has been reported as a cause of disseminated infection in patients after cardiac surgeries. Only a few cases associated with underlying lung diseases have been noted. infection is characterized by ambiguous symptoms. There is no treatment with proven effectiveness, and it has a poor prognosis. Silicosis is a disease that can predispose to mycobacterial infection. Silica damages pulmonary macrophages, inhibiting their ability to kill mycobacteria. We present a case of infection in a patient with silicosis and without other comorbidities. To our knowledge, it is the first case of silicosis associated with disease. A 45-year-old man presented with a persistent low-grade fever. Based on the clinical and radiological picture, positive cultures, and histological examination, the nontuberculous mycobacterial disease was diagnosed. First, multidrug therapy according to the treatment guidelines for was implemented, then antibiotics were administrated, based on drug sensitivity. Despite the treatment, eradication was not achieved and the patient died. The analysis of infection cases could contribute to developing recommendations and thus improve the prognosis.
是一种生长缓慢的非结核分枝杆菌（NTM），属于（）。它于2004年被鉴定为一个独特的物种。自2013年以来，它被报道为心脏手术后患者播散性感染的一个病因。仅发现少数与潜在肺部疾病相关的病例。感染的特征是症状不明确。没有经证实有效的治疗方法，且预后较差。矽肺是一种易引发分枝杆菌感染的疾病。二氧化硅会损害肺巨噬细胞，抑制其杀灭分枝杆菌的能力。我们报告一例矽肺且无其他合并症患者的感染病例。据我们所知，这是首例与疾病相关的矽肺病例。一名45岁男性出现持续低热。根据临床和影像学表现、阳性培养结果以及组织学检查，诊断为非结核分枝杆菌病。首先，根据的治疗指南实施多药治疗，然后根据药敏结果给予抗生素。尽管进行了治疗，但未实现根除，患者死亡。对感染病例的分析有助于制定建议，从而改善预后。
