Gastroenterology Unit, Department of Medical Specialties, University Hospital of Modena, University of Modena & Reggio Emilia, 41121 Modena, Italy.
Department of Medical and Surgical Sciences, University of Bologna, 40128 Bologna, Italy.
Int J Mol Sci. 2022 Aug 12;23(16):9016. doi: 10.3390/ijms23169016.
Vitamin D is a crucial nutrient with many pleiotropic effects on health and various chronic diseases. The purpose of this review is to provide a detailed report on the pathophysiological mechanisms underlying vitamin D deficiency in patients with chronic liver disease, addressing the different liver etiologies and the condition of advanced chronic liver disease (cirrhosis) with related complications. To date, patients with liver disease, regardless of underlying etiology, have been shown to have reduced levels of vitamin D. There is also evidence of the predictive role of vitamin D values in complications and progression of advanced disease. However, specific indications of vitamin D supplementation are not conclusive concerning what is already recommended in the general population. Future studies should make an effort to unify and validate the role of vitamin D supplementation in chronic liver disease.
维生素 D 是一种重要的营养物质，对健康和各种慢性疾病都有多种多效作用。本综述的目的是详细报告慢性肝病患者维生素 D 缺乏的病理生理机制，涉及不同的肝脏病因和晚期慢性肝病（肝硬化）及其相关并发症的情况。迄今为止，无论基础病因如何，肝病患者的维生素 D 水平都较低。也有证据表明维生素 D 值可预测晚期疾病的并发症和进展。然而，关于已经在普通人群中推荐的维生素 D 补充的具体适应症，尚无定论。未来的研究应努力统一和验证维生素 D 补充在慢性肝病中的作用。
