Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Int J Mol Sci. 2022 Aug 21;23(16):9446. doi: 10.3390/ijms23169446.
A progressive increase in maternal uterine and placental blood flow must occur during pregnancy to sustain the development of the fetus. Changes in maternal vasculature enable an increased uterine blood flow, placental nutrient and oxygen exchange, and subsequent fetal development. K channels are important modulators of vascular function, promoting vasodilation, inducing cell proliferation, and regulating cell signaling. Different types of K channels, such as Ca-activated, ATP-sensitive, and voltage-gated, have been implicated in the adaptation of maternal vasculature during pregnancy. Conversely, K channel dysfunction has been associated with vascular-related complications of pregnancy, including intrauterine growth restriction and pre-eclampsia. In this article, we provide an updated and comprehensive literature review that highlights the relevance of K channels as regulators of uterine vascular reactivity and their potential as therapeutic targets.
怀孕期间，母体子宫和胎盘血流必须逐渐增加，以维持胎儿的发育。母体血管的变化使子宫血流量增加，胎盘营养物质和氧气交换增加，从而促进胎儿发育。钾通道是血管功能的重要调节剂，可促进血管舒张、诱导细胞增殖和调节细胞信号转导。不同类型的钾通道，如钙激活、ATP 敏感和电压门控，与怀孕期间母体血管的适应有关。相反，钾通道功能障碍与妊娠相关的血管并发症有关，包括宫内生长受限和子痫前期。本文综述了钾通道作为子宫血管反应性调节剂的相关性及其作为治疗靶点的潜力，为您提供了最新、最全面的文献综述。
