Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 38 Gheorghe Marinescu Street, 540139 Targu Mures, Romania.
Research Center of Oncopathology and Transdisciplinary Research (CCOMT), George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540136 Targu Mures, Romania.
Int J Mol Sci. 2022 Aug 21;23(16):9455. doi: 10.3390/ijms23169455.
This historical review aimed to summarize the main changes that colorectal carcinoma (CRC) staging systems suffered over time, starting from the creation of the classical Duke's classification, modified Astler-Coller staging, internationally used TNM (T-primary tumor, N-regional lymph nodes' status, M-distant metastases) staging system, and ending with molecular classifications and epithelial-mesenchymal transition (EMT) concept. Besides currently used staging parameters, this paper briefly presents the author's contribution in creating an immunohistochemical (IHC)-based molecular classification of CRC. It refers to the identification of three molecular groups of CRCs (epithelial, mesenchymal and hybrid) based on the IHC markers E-cadherin, β-catenin, maspin, and vimentin. Maspin is a novel IHC antibody helpful for tumor budding assessment, which role depends on its subcellular localization (cytoplasm vs. nuclei). The long road of updating the staging criteria for CRC has not come to an end. The newest prognostic biomarkers, aimed to be included in the molecular classifications, exert predictive roles, and become more and more important for targeted therapy decisions.
这篇历史综述旨在总结结直肠癌（CRC）分期系统随时间的主要变化，从经典的 Duke 分类、改良的 Astler-Coller 分期、国际上使用的 TNM（T-原发肿瘤、N-区域淋巴结状态、M-远处转移）分期系统开始，最后介绍分子分类和上皮-间质转化（EMT）概念。除了目前使用的分期参数外，本文还简要介绍了作者在创建基于免疫组织化学（IHC）的 CRC 分子分类方面的贡献。它涉及根据 IHC 标志物 E-钙黏蛋白、β-连环蛋白、Maspin 和波形蛋白识别 CRC 的三个分子群（上皮、间质和混合）。Maspin 是一种有助于评估肿瘤芽生的新型 IHC 抗体，其作用取决于其亚细胞定位（细胞质与细胞核）。更新 CRC 分期标准的漫长道路尚未结束。最新的预后生物标志物旨在纳入分子分类，发挥预测作用，并对靶向治疗决策变得越来越重要。
Zotero 插件