Evaluation of Anti- Potential of Extract in Inhibiting Growth, Yeast-Hyphal Transition, Virulent Enzymes, and Biofilm Formation.

Due to the increased incidence of fungal infections and the emergence of antifungal resistance mainly by species, the need for safe and effective novel therapies is imperative. Consequently, plants and herbs are a powerful source to combat infections. Here, we evaluated the anti- potential of an ethanolic extract from The phytochemical analysis of revealed bioactive compounds such as alkaloids, terpenoids, and tannis. Our results showed that extract suppressed the virulence factors of strains, including hyphae formation in both liquid and solid media, reduced secretion of phospholipases/proteinases, and affected biofilm formation. Furthermore, the extract showed no hemolytic effect in vitro and exhibited reduced cytotoxicity on Vero cells and larvae at concentrations that inhibited hyphae and biofilm in Moreover, the extract demonstrated antifungal activity against strains. In conclusion, the extract affected the growth and morphogenesis of (even in resistant strains), demonstrating that this plant has an anti-candida activity and represents a promising resource for discovering novel antifungal compounds.