• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

提取物抑制生长、酵母-菌丝转变、毒力酶和生物膜形成的抗潜力评估。

Evaluation of Anti- Potential of Extract in Inhibiting Growth, Yeast-Hyphal Transition, Virulent Enzymes, and Biofilm Formation.

作者信息

Bravo-Chaucanés Claudia Patrícia, Vargas-Casanova Yerly, Chitiva-Chitiva Luis Carlos, Ceballos-Garzon Andrés, Modesti-Costa Geison, Parra-Giraldo Claudia Marcela

机构信息

Unidad de Proteómica y Micosis Humanas, Grupo de Enfermedades Infecciosas, Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá 110231, DC, Colombia.

Grupo de Investigación Fitoquímica Universidad Javeriana (GIFUJ), Departamento de Química, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá 110231, DC, Colombia.

出版信息

J Fungi (Basel). 2022 Jul 27;8(8):784. doi: 10.3390/jof8080784.

DOI:10.3390/jof8080784
PMID:36012773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9409899/
Abstract

Due to the increased incidence of fungal infections and the emergence of antifungal resistance mainly by species, the need for safe and effective novel therapies is imperative. Consequently, plants and herbs are a powerful source to combat infections. Here, we evaluated the anti- potential of an ethanolic extract from The phytochemical analysis of revealed bioactive compounds such as alkaloids, terpenoids, and tannis. Our results showed that extract suppressed the virulence factors of strains, including hyphae formation in both liquid and solid media, reduced secretion of phospholipases/proteinases, and affected biofilm formation. Furthermore, the extract showed no hemolytic effect in vitro and exhibited reduced cytotoxicity on Vero cells and larvae at concentrations that inhibited hyphae and biofilm in Moreover, the extract demonstrated antifungal activity against strains. In conclusion, the extract affected the growth and morphogenesis of (even in resistant strains), demonstrating that this plant has an anti-candida activity and represents a promising resource for discovering novel antifungal compounds.

摘要

由于真菌感染的发病率增加以及主要由某些物种引起的抗真菌耐药性的出现，迫切需要安全有效的新型疗法。因此，植物和草药是对抗感染的强大来源。在此，我们评估了[植物名称]乙醇提取物的抗[真菌名称]潜力。对[植物名称]的植物化学分析揭示了生物碱、萜类化合物和单宁等生物活性化合物。我们的结果表明，[植物名称]提取物抑制了[真菌名称]菌株的毒力因子，包括在液体和固体培养基中菌丝的形成，减少了磷脂酶/蛋白酶的分泌，并影响了生物膜的形成。此外，[植物名称]提取物在体外没有溶血作用，并且在抑制[真菌名称]菌丝和生物膜的浓度下，对Vero细胞和[幼虫名称]幼虫的细胞毒性降低。此外，该提取物对[真菌名称]菌株表现出抗真菌活性。总之，[植物名称]提取物影响了[真菌名称]（即使是耐药菌株）的生长和形态发生，表明这种植物具有抗念珠菌活性，是发现新型抗真菌化合物的有前途的资源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/454f45f8952e/jof-08-00784-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/d851d1871522/jof-08-00784-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/6134aa24e6eb/jof-08-00784-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/f0f03ea62bcc/jof-08-00784-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/440a68dc6ad2/jof-08-00784-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/da91b30342c6/jof-08-00784-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/1dcfbf14da22/jof-08-00784-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/6b64c1ba5300/jof-08-00784-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/d9fba3135211/jof-08-00784-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/454f45f8952e/jof-08-00784-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/d851d1871522/jof-08-00784-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/6134aa24e6eb/jof-08-00784-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/f0f03ea62bcc/jof-08-00784-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/440a68dc6ad2/jof-08-00784-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/da91b30342c6/jof-08-00784-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/1dcfbf14da22/jof-08-00784-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/6b64c1ba5300/jof-08-00784-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/d9fba3135211/jof-08-00784-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/9409899/454f45f8952e/jof-08-00784-g009.jpg

相似文献

1
Evaluation of Anti- Potential of Extract in Inhibiting Growth, Yeast-Hyphal Transition, Virulent Enzymes, and Biofilm Formation.提取物抑制生长、酵母-菌丝转变、毒力酶和生物膜形成的抗潜力评估。
J Fungi (Basel). 2022 Jul 27;8(8):784. doi: 10.3390/jof8080784.
2
Synergistic Interaction of Piperine and Thymol on Attenuation of the Biofilm Formation, Hyphal Morphogenesis and Phenotypic Switching in .胡椒碱和百里香酚协同作用对抑制生物膜形成、菌丝形态发生和表型转换的影响。
Front Cell Infect Microbiol. 2022 Jan 19;11:780545. doi: 10.3389/fcimb.2021.780545. eCollection 2021.
3
Inhibitory Effects of the Fungal Pigment Rubiginosin C on Hyphal and Biofilm Formation in and .真菌色素铁锈菌素C对[具体对象1]和[具体对象2]菌丝及生物膜形成的抑制作用
J Fungi (Basel). 2023 Jul 5;9(7):726. doi: 10.3390/jof9070726.
4
Exploring the Potential Mechanism of Action of Piperine against and Targeting Its Virulence Factors.探讨胡椒碱防治 及其毒力因子的潜在作用机制。
Biomolecules. 2023 Nov 30;13(12):1729. doi: 10.3390/biom13121729.
5
The Emerging Pathogen Candida auris: Growth Phenotype, Virulence Factors, Activity of Antifungals, and Effect of SCY-078, a Novel Glucan Synthesis Inhibitor, on Growth Morphology and Biofilm Formation.新兴病原体耳念珠菌：生长表型、毒力因子、抗真菌药物活性以及新型葡聚糖合成抑制剂SCY-078对生长形态和生物膜形成的影响
Antimicrob Agents Chemother. 2017 Apr 24;61(5). doi: 10.1128/AAC.02396-16. Print 2017 May.
6
Dracorhodin perchlorate inhibits biofilm formation and virulence factors of Candida albicans.过氯酸血根碱抑制白色念珠菌生物膜形成和毒力因子。
J Mycol Med. 2018 Mar;28(1):36-44. doi: 10.1016/j.mycmed.2017.12.011. Epub 2018 Feb 22.
7
Anti- Potential of Sclareol in Inhibiting Growth, Biofilm Formation, and Yeast-Hyphal Transition.香紫苏醇抑制生长、生物膜形成及酵母-菌丝转变的潜力
J Fungi (Basel). 2023 Jan 10;9(1):98. doi: 10.3390/jof9010098.
8
Yeast-Host Interactions: Modulates Virulence Factors of and Inflammatory Response .酵母与宿主的相互作用：调节（病原体的）毒力因子和炎症反应。
Front Pharmacol. 2021 Jun 8;12:629778. doi: 10.3389/fphar.2021.629778. eCollection 2021.
9
Inhibition of Biofilm Formation by and Polymicrobial Microorganisms by Nepodin via Hyphal-Growth Suppression.Nepodin通过抑制菌丝生长对单微生物和多微生物生物膜形成的抑制作用。
ACS Infect Dis. 2019 Jul 12;5(7):1177-1187. doi: 10.1021/acsinfecdis.9b00033. Epub 2019 May 10.
10
β-citronellol alters cell surface properties of Candida albicans to influence pathogenicity related traits.β-香茅醇改变白色念珠菌的细胞表面特性，从而影响与致病性相关的特征。
Med Mycol. 2020 Jan 1;58(1):93-106. doi: 10.1093/mmy/myz009.

引用本文的文献

1
Chemical Composition, Biocompatibility, and Anti- Activity of Mart. ex Engl.马特（Mart.）前英文名称的化学成分、生物相容性及抗活性
Pathogens. 2025 Aug 9;14(8):799. doi: 10.3390/pathogens14080799.
2
Bioactive Plant Compounds as Alternatives Against Antifungal Resistance in the Strains.生物活性植物化合物作为对抗菌株中抗真菌耐药性的替代物。
Pharmaceutics. 2025 May 23;17(6):687. doi: 10.3390/pharmaceutics17060687.
3
Synergistic Effect of Essential Oils and Antifungal Agents in Fighting Resistant Clinical Isolates of .精油与抗真菌剂在对抗耐药临床分离株方面的协同作用。 （注：原文结尾处不完整）

本文引用的文献

1
Fragmentation pattern of amides by EI and HRESI: study of protonation sites using DFT-3LYP data.EI和HRESI作用下酰胺的裂解模式：利用DFT-3LYP数据研究质子化位点
RSC Adv. 2018 Jun 12;8(38):21407-21413. doi: 10.1039/c7ra00408g. eCollection 2018 Jun 8.
2
Emerging Antifungal Targets and Strategies.新兴抗真菌靶点和策略。
Int J Mol Sci. 2022 Mar 2;23(5):2756. doi: 10.3390/ijms23052756.
3
Genotypic, proteomic, and phenotypic approaches to decipher the response to caspofungin and calcineurin inhibitors in clinical isolates of echinocandin-resistant Candida glabrata.
Pharmaceutics. 2024 Jul 19;16(7):957. doi: 10.3390/pharmaceutics16070957.
4
HPLC, NMR Based Characterization, Antioxidant and Anticancer Activities of Chemical Constituents from Therapeutically Active Fungal Endophytes.基于高效液相色谱（HPLC）和核磁共振（NMR）的鉴定、药用真菌内生菌化学成分的抗氧化和抗癌活性研究。
J Microbiol Biotechnol. 2024 Jul 28;34(7):1452-1463. doi: 10.4014/jmb.2403.03036. Epub 2024 May 6.
5
Exploring the Potential Mechanism of Action of Piperine against and Targeting Its Virulence Factors.探讨胡椒碱防治 及其毒力因子的潜在作用机制。
Biomolecules. 2023 Nov 30;13(12):1729. doi: 10.3390/biom13121729.
6
Evaluating the Activity and Safety of Modified LfcinB Peptides as Potential Colon Anticancer Agents: Cell Line Studies and Insect-Based Toxicity Assessments.评估修饰的乳铁传递蛋白B肽作为潜在结肠抗癌剂的活性和安全性：细胞系研究和基于昆虫的毒性评估。
ACS Omega. 2023 Oct 4;8(41):37948-37957. doi: 10.1021/acsomega.3c03455. eCollection 2023 Oct 17.
7
Valorisation of the Invasive Macroalgae (Harvey) Suringar for the Green Synthesis of Gold and Silver Nanoparticles with Antimicrobial and Antioxidant Potential.（ Harvey）Suringar 入侵性大型藻类的增值用于绿色合成具有抗菌和抗氧化潜力的金和银纳米粒子。
Mar Drugs. 2023 Jul 9;21(7):397. doi: 10.3390/md21070397.
8
A semi purified hydroalcoholic fraction from seeds causes ergosterol biosynthesis inhibition in resulting in cell membrane damage.种子中的半纯化水醇提取物会导致麦角固醇生物合成受到抑制，进而造成细胞膜损伤。
Front Pharmacol. 2023 Jun 12;14:1189241. doi: 10.3389/fphar.2023.1189241. eCollection 2023.
9
Changes in Length and Positive Charge of Palindromic Sequence RWQWRWQWR Enhance Cytotoxic Activity against Breast Cancer Cell Lines.回文序列RWQWRWQWR的长度和正电荷变化增强了对乳腺癌细胞系的细胞毒性活性。
ACS Omega. 2023 Jan 5;8(2):2712-2722. doi: 10.1021/acsomega.2c07336. eCollection 2023 Jan 17.
10
Anti- Potential of Sclareol in Inhibiting Growth, Biofilm Formation, and Yeast-Hyphal Transition.香紫苏醇抑制生长、生物膜形成及酵母-菌丝转变的潜力
J Fungi (Basel). 2023 Jan 10;9(1):98. doi: 10.3390/jof9010098.
基因分型、蛋白质组学和表型方法解析临床分离的棘白菌素耐药近平滑念珠菌对卡泊芬净和钙调磷酸酶抑制剂的反应。
J Antimicrob Chemother. 2022 Feb 23;77(3):585-597. doi: 10.1093/jac/dkab454.
4
Forward and reverse genetic dissection of morphogenesis identifies filament-competent Candida auris strains.正向和反向遗传学解析形态发生，鉴定出有丝分裂能力的耳念珠菌菌株。
Nat Commun. 2021 Dec 10;12(1):7197. doi: 10.1038/s41467-021-27545-5.
5
A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase.一种由乳杆菌属产生的小分子通过抑制 DYRK1 家族激酶来阻止白念珠菌的菌丝形成。
Nat Commun. 2021 Oct 22;12(1):6151. doi: 10.1038/s41467-021-26390-w.
6
Antibiofilm Potential of Medicinal Plants against spp. Oral Biofilms: A Review.药用植物对口腔生物膜的抗生物膜潜力：综述
Antibiotics (Basel). 2021 Sep 21;10(9):1142. doi: 10.3390/antibiotics10091142.
7
Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation.具有抗菌和抗病毒作用的天然化合物及其用于运输的纳米载体
Front Pharmacol. 2021 Sep 6;12:723233. doi: 10.3389/fphar.2021.723233. eCollection 2021.
8
Antioxidant, antibacterial, and antimutagenic activity of seeds extracts.种子提取物的抗氧化、抗菌和抗诱变活性。
Saudi J Biol Sci. 2021 Sep;28(9):5094-5105. doi: 10.1016/j.sjbs.2021.05.030. Epub 2021 May 20.
9
Candida albicans colonization of the gastrointestinal tract: A double-edged sword.白色念珠菌在胃肠道的定植：一把双刃剑。
PLoS Pathog. 2021 Jul 22;17(7):e1009710. doi: 10.1371/journal.ppat.1009710. eCollection 2021 Jul.
10
Intravital Imaging of Candida albicans Identifies Differential and Filamentation Phenotypes for Transcription Factor Deletion Mutants.活体成像鉴定白念珠菌中转录因子缺失突变株的差异和菌丝形成表型。
mSphere. 2021 Jun 30;6(3):e0043621. doi: 10.1128/mSphere.00436-21. Epub 2021 Jun 23.