Mijaljica Dalibor, Spada Fabrizio, Harrison Ian P
Department of Scientific Affairs, Ego Pharmaceuticals Pty Ltd., 21-31 Malcolm Road, Braeside, VIC 3195, Australia.
J Fungi (Basel). 2022 Aug 1;8(8):812. doi: 10.3390/jof8080812.
A broad range of topical antifungal formulations containing miconazole or terbinafine as actives are commonly used as efficacious choices for combating fungal skin infections. Their many benefits, owing to their specific mechanism of action, include their ability to target the site of infection, enhance treatment efficacy and reduce the risk of systemic side effects. Their proven efficacy, and positioning in the treatment of fungal skin infections, is enhanced by high patient compliance, especially when appropriate vehicles such as creams, ointments and gels are used. However, inflammation as a result of fungal infection can often impede treatment, especially when combined with pruritus (itch), an unpleasant sensation that elicits an urge to scratch. The scratching that occurs in response to pruritus frequently accelerates skin damage, ultimately aggravating and spreading the fungal infection. To help overcome this issue, a topical antifungal-corticosteroid combination consisting of miconazole or terbinafine and corticosteroids of varying potencies should be used. Due to their inherent benefits, these topical antifungal-corticosteroid combinations can concomitantly and competently attenuate inflammation, relieve pruritus and treat fungal infection.
多种含有咪康唑或特比萘芬作为活性成分的局部用抗真菌制剂通常被用作对抗真菌性皮肤感染的有效选择。由于其特定的作用机制，它们有诸多益处，包括能够靶向感染部位、提高治疗效果以及降低全身性副作用的风险。高患者依从性提升了它们已被证实的疗效以及在真菌性皮肤感染治疗中的地位，尤其是当使用乳膏、软膏和凝胶等合适的剂型时。然而，真菌感染引起的炎症常常会妨碍治疗，特别是当伴有瘙痒（痒）时，瘙痒是一种令人不适的感觉，会引发搔抓冲动。因瘙痒而发生的搔抓常常会加速皮肤损伤，最终加重并扩散真菌感染。为帮助克服这一问题，应使用由咪康唑或特比萘芬与不同强度的皮质类固醇组成的局部用抗真菌 - 皮质类固醇复方制剂。由于其固有的益处，这些局部用抗真菌 - 皮质类固醇复方制剂可以同时有效地减轻炎症、缓解瘙痒并治疗真菌感染。
