IRD, AP-HM, MEPHI, Aix Marseille Université, Marseille, France.
IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13385, Marseille Cedex 05, France.
Microbiome. 2021 May 30;9(1):125. doi: 10.1186/s40168-021-01062-5.
The skin is the exterior interface of the human body with the environment. Despite its harsh physical landscape, the skin is colonized by diverse commensal microbes. In this review, we discuss recent insights into skin microbial populations, including their composition and role in health and disease and their modulation by intrinsic and extrinsic factors, with a focus on the pathobiological basis of skin aging. We also describe the most recent tools for investigating the skin microbiota composition and microbe-skin relationships and perspectives regarding the challenges of skin microbiome manipulation. Video abstract.
皮肤是人体与环境的外部接口。尽管其物理环境恶劣，但皮肤仍被各种共生微生物所定植。在这篇综述中，我们讨论了皮肤微生物群的最新研究进展，包括它们的组成、在健康和疾病中的作用，以及内在和外在因素对其的调节，重点是皮肤衰老的病理生物学基础。我们还描述了最新的研究皮肤微生物组组成和微生物-皮肤关系的工具，以及皮肤微生物组操作所面临的挑战的相关观点。视频摘要。
