Striukova Evgeniia Vital'evna, Shramko Victoriya Sergeevna, Kashtanova Elena Vladimirovna, Polonskaya Yana Vladimirovna, Stakhneva Ekaterina Mikhailovna, Kurguzov Alexey Vitalievich, Chernyavsky Alexander Mikhailovich, Ragino Yulia Igorevna
Research Institute of Internal and Preventive Medicine-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of IC&G SB RAS), B. Bogatkova Str., 175/1, 630089 Novosibirsk, Russia.
The Federal State Budgetary Institution "National Medical Research Center Named Academician E.N. Meshalkin" of the Ministry of Health of the Russian Federation, Rechkunovskaya Str., 15, 630055 Novosibirsk, Russia.
J Pers Med. 2022 Jul 29;12(8):1248. doi: 10.3390/jpm12081248.
Obesity is associated with dyslipidemia, and excess body fat is associated with unfavorable levels of adipokines and markers of inflammation. To study the level of adipokines and markers of inflammation, their associations with unstable atherosclerotic plaques in men with coronary atherosclerosis on the background of abdominal obesity. The study involved 82 men aged 40-77 years with coronary atherosclerosis after endarterectomy from the coronary arteries. We divided all men into two groups: 37 men (45.1%) with unstable atherosclerotic plaques, and 45 men (54.9%) who had stable plaques. Obesity was established at a BMI of ≥30 kg/m. The levels of adipokines and markers of inflammation in the blood were determined by multiplex analysis. In patients with obesity and unstable plaques, the levels of C-peptide, TNFa and IL-6 were 1.8, 1.6, and 2.8 times higher, respectively, than in patients with obesity and stable plaques. The chance of having an unstable plaque increases with an increase in TNFa by 49% in obese patients and decreases with an increase in insulin by 3% in non-obese patients. In men with coronary atherosclerosis and obesity, unstable atherosclerotic plaques in the coronary arteries are directly associated with the level of TNF-α.
肥胖与血脂异常相关，过多的体脂与脂肪因子水平及炎症标志物异常有关。为研究脂肪因子水平及炎症标志物，以及在腹型肥胖背景下，它们与冠状动脉粥样硬化男性患者不稳定动脉粥样硬化斑块之间的关联。该研究纳入了82名年龄在40 - 77岁之间、接受过冠状动脉内膜切除术且患有冠状动脉粥样硬化的男性。我们将所有男性分为两组：37名男性（45.1%）有不稳定动脉粥样硬化斑块，45名男性（54.9%）有稳定斑块。肥胖定义为BMI≥30 kg/m²。通过多重分析测定血液中脂肪因子水平及炎症标志物。在肥胖且有不稳定斑块的患者中，C肽、TNFα和IL - 6水平分别比肥胖且有稳定斑块的患者高1.8倍、1.6倍和2.8倍。肥胖患者中，TNFα每增加，出现不稳定斑块的几率增加49%；非肥胖患者中，胰岛素每增加，出现不稳定斑块的几率降低3%。在患有冠状动脉粥样硬化和肥胖的男性中，冠状动脉内的不稳定动脉粥样硬化斑块与TNF -α水平直接相关。
