不稳定动脉粥样硬化斑块和腹型肥胖患者的脂肪细胞因子-细胞因子谱。

Adipokine-Cytokine Profile in Patients with Unstable Atherosclerotic Plaques and Abdominal Obesity.

机构信息

Research Institute of Internal and Preventive Medicine-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of IC&G SB RAS), B. Bogatkova Str., 175/1, 630089 Novosibirsk, Russia.

Federal State Budgetary Institution "National Medical Research Center named after Academician E.N. Meshalkin" Ministry of Health of the Russian Federation, Rechkunovskaya Str., 15, 630055 Novosibirsk, Russia.

出版信息

Int J Mol Sci. 2023 May 18;24(10):8937. doi: 10.3390/ijms24108937.

DOI:10.3390/ijms24108937

PMID:37240282

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10219199/

Abstract

UNLABELLED

The goal of the research was to study the levels of adipokines and their associations with unstable atherosclerotic plaques in patients with coronary atherosclerosis and abdominal obesity (AO).

METHODS

The study included 145 men aged 38-79 with atherosclerosis of the coronary arteries (CA) and stable angina pectoris II-III FC who were hospitalized for coronary bypass surgery (2011-2022). The final analysis included 116 patients. Notably, 70 men had stable plaques in the CA (of which 44.3% had AO), and 46 men had unstable plaques in the CA (of which 43.5% had AO). Adipocytokine levels were determined using multiplex analysis (Human Metabolic Hormone V3 panel).

RESULTS

In the subgroup of patients with unstable plaques, patients with AO had a GLP-1 level that was 1.5 times higher and a lipocalin-2 level that was 2.1 times lower, respectively. GLP-1 is direct, and lipocalin-2 is inversely associated with AO in patients with unstable plaques. Among patients with AO, the level of lipocalin-2 in patients with unstable plaques was 2.2 times lower than in patients with stable plaques in the CA. The level of lipocalin-2 was inversely associated with the presence of unstable atherosclerotic plaques in the CA.

CONCLUSION

GLP-1 is directly associated with AO in patients with unstable atherosclerotic plaques. Lipocalin-2 is inversely associated with unstable atherosclerotic plaques in patients with AO.

摘要

目的

研究冠心病伴腹型肥胖患者中脂肪细胞因子水平及其与不稳定粥样斑块的关系。

方法

纳入 2011 年至 2022 年因冠状动脉旁路移植术住院的 145 例年龄 38-79 岁、有冠状动脉粥样硬化且稳定型心绞痛Ⅱ-Ⅲ FC 的男性患者。最终分析纳入 116 例患者。其中 70 例男性患者冠状动脉有稳定斑块（44.3%有腹型肥胖），46 例男性患者冠状动脉有不稳定斑块（43.5%有腹型肥胖）。采用多重分析（人代谢激素 V3 面板）测定脂肪细胞因子水平。

结果

在不稳定斑块患者亚组中，腹型肥胖的患者 GLP-1 水平高 1.5 倍，脂联素-2 水平低 2.1 倍。GLP-1 与不稳定斑块直接相关，脂联素-2 与不稳定斑块呈负相关。在有腹型肥胖的患者中，不稳定斑块患者的脂联素-2 水平比稳定斑块患者低 2.2 倍。脂联素-2 水平与冠状动脉不稳定粥样斑块的存在呈负相关。