León Aguilera Xavier Eugenio, Manzano Alexander, Pirela Daniela, Bermúdez Valmore
Departamento de Post-Grado, Universidad Católica de Cuenca, Ciudad Cuenca 010109, Ecuador.
Endocrine and Metabolic Diseases Research Center, School of Medicine, Universidad del Zulia, Maracaibo 4002, Venezuela.
J Pers Med. 2022 Aug 4;12(8):1282. doi: 10.3390/jpm12081282.
Obesity and its comorbidities are humans' most prevalent cardio-metabolic diseases worldwide. Recent evidence has shown that chronic low-grade inflammation is a common feature in all highly prevalent chronic degenerative diseases. In this sense, the gut microbiota is a complete ecosystem involved in different processes like vitamin synthesis, metabolism regulation, and both appetite and immune system control. Thus, dysbiosis has been recognised as one of the many factors associated with obesity due to a predominance of , a decrease in in the gut, and a consequent short-chain fatty acids (SCFA) synthesis reduction leading to a reduction in incretins action and intestinal permeability increase. In this context, bacteria, bacterial endotoxins, and toxic bacterial by-products are translocated to the bloodstream, leading to systemic inflammation. This review focuses on gut microbiota composition and its role in obesity, as well as probiotics and prebiotics benefits in obesity.
肥胖及其合并症是全球人类最普遍的心血管代谢疾病。最近的证据表明，慢性低度炎症是所有高度流行的慢性退行性疾病的一个共同特征。从这个意义上说，肠道微生物群是一个完整的生态系统，参与维生素合成、代谢调节以及食欲和免疫系统控制等不同过程。因此，由于肠道中某种菌占优势、另一种菌减少，以及随之而来的短链脂肪酸（SCFA）合成减少导致肠促胰岛素作用降低和肠道通透性增加，生态失调已被认为是与肥胖相关的众多因素之一。在这种情况下，细菌、细菌内毒素和有毒的细菌副产物会转移到血液中，导致全身炎症。本综述重点关注肠道微生物群的组成及其在肥胖中的作用，以及益生菌和益生元对肥胖的益处。
