Ermolenko Elena, Kotyleva Marina, Kotrova Anna, Tichonov Sergey, Lavrenova Nadezhda, Voropaeva Lyubov, Topalova Yulia, Karaseva Alena, Azarov Daniil, Ermolenko Konstantin, Druzhininskii Dmitrii, Dmitriev Alexander, Shishkin Alexander, Suvorov Alexander
Federal State Budgetary Institution "Institute of Experimental Medicine", 197376 Saint-Petersburg, Russia.
Medical Faculty, Saint-Petersburg State University, 199034 Saint-Petersburg, Russia.
Microorganisms. 2022 Aug 5;10(8):1574. doi: 10.3390/microorganisms10081574.
The features of gut microbiota in metabolic syndrome (MS) and ways to correct it using autoprobiotics, based on indigenous bacteria obtained from fecal samples of the host, remain unexplored. The aim of the study was to investigate the effectiveness of an indigenous consortium (IC) of fecal bacteria in treatment of patients with MS. The study was carried out on 36 patients with MS, manifested with abdominal obesity, eating disorders, dyslipidemia, and hypertension. The control group was formed by 20 healthy volunteers. Samples of IC and gut microbiota content were examined by qPCR and metagenome (16S rRNA) analysis before and after therapy. The decrease in anthropometric parameters of obesity, liver enzyme level correction, reduction in C reactive protein and triglyceride concentrations were revealed after IC usage. The decrease in genera , , , and , as well as an increase in and spp. populations were shown after consumption of IC. A negative correlation between the quantity of and the anthropometric parameters of obesity (r = -0.48) and C reactive protein level (r = -0.36) in serum was established. Thus, IC can be considered as a potential functional personified product for the therapy of MS.
代谢综合征（MS）中肠道微生物群的特征以及基于从宿主粪便样本中获取的本土细菌使用自身益生菌来纠正该综合征的方法仍未得到探索。本研究的目的是调查粪便细菌的本土菌群（IC）对MS患者的治疗效果。该研究针对36名患有MS的患者开展，这些患者表现为腹部肥胖、饮食失调、血脂异常和高血压。对照组由20名健康志愿者组成。在治疗前后，通过qPCR和宏基因组（16S rRNA）分析对IC和肠道微生物群含量样本进行检测。使用IC后，肥胖的人体测量参数降低、肝酶水平得到纠正、C反应蛋白和甘油三酯浓度降低。食用IC后，显示出属、、、和的数量减少，以及和 spp. 种群增加。血清中和肥胖的人体测量参数（r = -0.48）以及C反应蛋白水平（r = -0.36）之间建立了负相关。因此，IC可被视为治疗MS的一种潜在功能性个性化产品。
