白蛋白稳定的Fe@C核壳纳米颗粒作为磁热疗候选材料

Albumin Stabilized Fe@C Core-Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy.

作者信息

Ramírez-Morales Maria Antonieta, Goldt Anastasia E, Kalachikova Polina M, Ramirez B Javier A, Suzuki Masashi, Zhigach Alexey N, Ben Salah Asma, Shurygina Liliya I, Shandakov Sergey D, Zatsepin Timofei, Krasnikov Dmitry V, Maekawa Toru, Nikolaev Evgeny N, Nasibulin Albert G

机构信息

Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia.

Hi-QNano s.r.l., Via Barsanti No. 1, 73010 Arnesano, Italy.

出版信息

Nanomaterials (Basel). 2022 Aug 20;12(16):2869. doi: 10.3390/nano12162869.

DOI:10.3390/nano12162869

PMID:36014734

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9414223/

Abstract

Carbon-encapsulated iron nanoparticles (Fe@C) with a mean diameter of 15 nm have been synthesized using evaporation-condensation flow-levitation method by the direct iron-carbon gas-phase reaction at high temperatures. Further, Fe@C were stabilized with bovine serum albumin (BSA) coating, and their electromagnetic properties were evaluated to test their performance in magnetic hyperthermia therapy (MHT) through a specific absorption rate (SAR). Heat generation was observed at different Fe@C concentrations (1, 2.5, and 5 mg/mL) when applied 331 kHz and 60 kA/m of an alternating magnetic field, resulting in SAR values of 437.64, 129.36, and 50.4 W/g for each concentration, respectively. Having such high SAR values at low concentrations, obtained material is ideal for use in MHT.

摘要

采用蒸发-冷凝流动悬浮法，通过高温下铁-碳直接气相反应合成了平均直径为15 nm的碳包覆铁纳米颗粒（Fe@C）。此外，用牛血清白蛋白（BSA）涂层对Fe@C进行了稳定化处理，并通过比吸收率（SAR）评估了它们的电磁性能，以测试其在磁热疗（MHT）中的性能。当施加331 kHz和60 kA/m的交变磁场时，在不同的Fe@C浓度（1、2.5和5 mg/mL）下观察到了发热现象，每种浓度下的SAR值分别为437.64、129.36和50.4 W/g。由于在低浓度下具有如此高的SAR值，所获得的材料是磁热疗的理想选择。