用于细胞技术的基于壳聚糖和单壁碳纳米管的导电复合材料。

Conducting Composite Material Based on Chitosan and Single-Wall Carbon Nanotubes for Cellular Technologies.

作者信息

Kodolova-Chukhontseva Vera Vladimirovna, Shishov Mikhail Alexandrovich, Kolbe Konstantin Andreevich, Smirnova Natalia Vladimirovna, Dobrovol'skaya Irina Petrovna, Dresvyanina Elena Nikolaevna, Bystrov Sergei Gennadievich, Terebova Nadezda Semenovna, Kamalov Almaz Maratovich, Bursian Anna Ericovna, Ivan'kova Elena Mikhailovna, Yudin Vladimir Evgenievich

机构信息

Research Laboratory "Polymer Materials for Tissue Engineering and Transplantology", Institute of Biomedical Systems and Biotechnology, Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya Street, 29, 195251 Saint-Petersburg, Russia.

Laboratory No 8-Mechanics of Polymers and Composite, Institute of Macromolecular Compounds Russian Academy of Science, V.O., Bolshoy pr. 31, 199004 Saint-Petersburg, Russia.

出版信息

Polymers (Basel). 2022 Aug 12;14(16):3287. doi: 10.3390/polym14163287.

DOI:10.3390/polym14163287

PMID:36015544

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9413541/

Abstract

Biocompatible electrically conducting chitosan-based films filled with single-wall carbon nanotubes were obtained. Atomic force microscopic studies of the free surface topography revealed a change in the morphology of chitosan films filled with single-wall carbon nanotubes. Introducing 0.5 wt.% of single-wall carbon nanotubes into chitosan results in an increase in tensile strength of the films (up to ~180 MPa); the tensile strain values also rise up to ~60%. It was demonstrated that chitosan films containing 0.1-3.0 wt.% of single-wall carbon nanotubes have higher conductivity (10 S/m) than pure chitosan films (10 S/m). The investigation of electrical stimulation of human dermal fibroblasts on chitosan/single-wall carbon nanotubes film scaffolds showed that the biological effect of cell electrical stimulation depends on the content of single-walled carbon nanotubes in the chitosan matrix.

摘要

制备了填充有单壁碳纳米管的生物相容性导电壳聚糖基薄膜。对自由表面形貌的原子力显微镜研究表明，填充有单壁碳纳米管的壳聚糖薄膜的形态发生了变化。向壳聚糖中引入0.5 wt.%的单壁碳纳米管会导致薄膜的拉伸强度增加（高达~~180 MPa）；拉伸应变值也上升至~~60%。结果表明，含有0.1 - 3.0 wt.%单壁碳纳米管的壳聚糖薄膜比纯壳聚糖薄膜具有更高的电导率（10 S/m）。对壳聚糖/单壁碳纳米管薄膜支架上的人真皮成纤维细胞进行电刺激研究表明，细胞电刺激的生物学效应取决于壳聚糖基质中单壁碳纳米管的含量。