Beró T
Acta Med Hung. 1986;43(4):369-72.
The effect in rats of cyclophosphamide and vincristine on glucose absorption was studied by the in vivo perfusion method. On testing the local effect of cytostatics, the drugs were dissolved in the perfusion solution, cyclophosphamide at a concentration of 10(-4) M and vincristine at 10(-6) M. Glucose absorption was not reduced by cyclophosphamide, while it was significantly reduced by vincristine. On testing the systemic effect of cytostatics, the drugs were administered intraperitoneally 24 hours prior to perfusion, i.e. in doses of 80 mg/kg in the case of cyclophosphamide, and of 0.05 mg/kg of vincristine. In that case, both cytostatics decreased glucose absorption significantly. Based on the results it was found that, being administered locally, cyclophosphamide did not have a damaging effect on the intestinal wall, and did not reduce absorption either. On the contrary, vincristine impaired the mucosa locally, thereby reducing glucose absorption. On systemic administration, both cytostatics decreased absorption from the small intestine.
采用体内灌注法研究了环磷酰胺和长春新碱对大鼠葡萄糖吸收的影响。在测试细胞抑制剂的局部作用时，将药物溶解于灌注液中，环磷酰胺浓度为10（-4）M，长春新碱浓度为10（-6）M。环磷酰胺未降低葡萄糖吸收，而长春新碱则使其显著降低。在测试细胞抑制剂的全身作用时，于灌注前24小时腹腔注射药物，即环磷酰胺剂量为80mg/kg，长春新碱剂量为0.05mg/kg。在这种情况下，两种细胞抑制剂均显著降低葡萄糖吸收。基于这些结果发现，局部给药时，环磷酰胺对肠壁无损害作用，也不降低吸收。相反，长春新碱局部损伤黏膜，从而降低葡萄糖吸收。全身给药时，两种细胞抑制剂均降低小肠吸收。
