Hajissa Khalid, Mussa Ali, Karobari Mohmed Isaqali, Abbas Muhammad Adamu, Ibrahim Ibrahim Khider, Assiry Ali A, Iqbal Azhar, Alhumaid Saad, Mutair Abbas Al, Rabaan Ali A, Messina Pietro, Scardina Giuseppe Alessandro
Department of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia.
Department of Zoology, Faculty of Science and Technology, Omdurman Islamic University, Omdurman P.O. Box 382, Sudan.
Vaccines (Basel). 2022 Aug 18;10(8):1346. doi: 10.3390/vaccines10081346.
Antibodies (Abs) are important immune mediators and powerful diagnostic markers in a wide range of infectious diseases. Understanding the humoral immunity or the development of effective antibodies against SARS-CoV-2 is a prerequisite for limiting disease burden in the community and aids in the development of new diagnostic, therapeutic, and vaccination options. Accordingly, the role of antiviral antibodies in the resistance to and diagnosis of SARS-CoV-2 infection was explored. Antibody testing showed the potential in adding important diagnostic value to the routine diagnosis and clinical management of COVID-19. They could also play a critical role in COVID-19 surveillance, allowing for a better understanding of the full scope of the disease. The development of several vaccines and the success of passive immunotherapy suggest that anti-SARS-CoV-2 antibodies have the potential to be used in the treatment and prevention of SARS-CoV-2 infection. In this review, we highlight the role of antibodies in the diagnosis of SARS-CoV-2 infection and provide an update on their protective roles in controlling SARS-CoV-2 infection as well as vaccine development.
抗体（Abs）是重要的免疫介质，也是多种传染病中强大的诊断标志物。了解体液免疫或针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）产生有效抗体是限制社区疾病负担的先决条件，有助于开发新的诊断、治疗和疫苗接种方案。因此，研究了抗病毒抗体在抵抗和诊断SARS-CoV-2感染中的作用。抗体检测显示出在为2019冠状病毒病（COVID-19）的常规诊断和临床管理增加重要诊断价值方面的潜力。它们在COVID-19监测中也可发挥关键作用，有助于更好地了解该疾病的全貌。几种疫苗的研发以及被动免疫疗法的成功表明，抗SARS-CoV-2抗体有潜力用于治疗和预防SARS-CoV-2感染。在本综述中，我们强调了抗体在诊断SARS-CoV-2感染中的作用，并提供了关于它们在控制SARS-CoV-2感染以及疫苗研发中的保护作用的最新情况。
