Neumann F J, Schmid-Schönbein H, Ohlenbusch H
Pflugers Arch. 1987 May;408(5):524-30. doi: 10.1007/BF00585080.
To investigate the temperature-dependence of red cell aggregation 20 blood samples of normal donors and 20 blood samples of patients with venous ulcers of the leg were examined by photometric aggregometry at 3 degrees C, 10 degrees C, 20 degrees C, 30 degrees C and 37 degrees C. With decreasing temperature red cell aggregates become more resistant to hydrodynamic dispersion and they become more prone to growing under low shear stress. It is concluded that a decrease in temperature causes an increase in adsorptive energy of red cell aggregation, which is most likely due to an increase in molecular adsorption stress. Red cell aggregate formation as an overall process is retarded by a decrease in temperature, which is primarily due to an increase in plasma viscosity causing increased damping of aggregate formation. Accordingly the rate constant of aggregate formation corrected for plasma viscosity increases with decreasing temperature. The temperature-dependence of the kinetic parameters can be explained by a theoretical model that suggests the increase in contact area between aggregating red blood cells as the rate-limiting step of red cell aggregation. As a whole red cell aggregation is favoured by lowering of temperature.
为研究红细胞聚集的温度依赖性，采用光度聚集测定法，在3℃、10℃、20℃、30℃和37℃下，对20份正常献血者的血样和20份腿部静脉溃疡患者的血样进行了检测。随着温度降低，红细胞聚集体对流体动力学分散的抵抗力增强，且在低剪切应力下更易于生长。得出的结论是，温度降低会导致红细胞聚集吸附能增加，这很可能是由于分子吸附应力增加所致。作为一个整体过程，红细胞聚集体的形成因温度降低而延迟，这主要是由于血浆粘度增加导致聚集体形成的阻尼增加。因此，校正血浆粘度后的聚集体形成速率常数随温度降低而增加。动力学参数的温度依赖性可以用一个理论模型来解释，该模型表明聚集红细胞之间接触面积的增加是红细胞聚集的限速步骤。总体而言，降低温度有利于红细胞聚集。
