Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
Shanghai Public Health Clinical Center, Department of Laboratory Medicine, Shanghai 201508, China.
Viruses. 2022 Aug 15;14(8):1774. doi: 10.3390/v14081774.
The gut microbiota is essential for good health. It has also been demonstrated that the gut microbiota can regulate immune responses against respiratory tract infections. Since the outbreak of the COVID-19 pandemic, accumulating evidence suggests that there is a link between the severity of COVID-19 and the alteration of one's gut microbiota. The composition of gut microbiota can be profoundly affected by COVID-19 and vice versa. Here, we summarize the observations of the mutual impact between SARS-CoV-2 infection and gut microbiota composition. We discuss the consequences and mechanisms of the bi-directional interaction. Moreover, we also discuss the immune cross-reactivity between SARS-CoV-2 and commensal bacteria, which represents a previously overlooked connection between COVID-19 and commensal gut bacteria. Finally, we summarize the progress in managing COVID-19 by utilizing microbial interventions.
肠道微生物群对于健康至关重要。已经证明，肠道微生物群可以调节针对呼吸道感染的免疫反应。自 COVID-19 大流行爆发以来，越来越多的证据表明，COVID-19 的严重程度与肠道微生物群的改变之间存在关联。肠道微生物群的组成可以受到 COVID-19 的深远影响，反之亦然。在这里，我们总结了 SARS-CoV-2 感染和肠道微生物群组成之间相互影响的观察结果。我们讨论了双向相互作用的后果和机制。此外，我们还讨论了 SARS-CoV-2 与共生细菌之间的免疫交叉反应，这代表了 COVID-19 与共生肠道细菌之间以前被忽视的联系。最后，我们总结了利用微生物干预来管理 COVID-19 的进展。
