Huang Qian, Xin Xin, Sun QinMei, An Ziming, Gou Xiaojun, Feng Qin
Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Central Laboratory, Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine of Shanghai, Shanghai, China.
Front Pharmacol. 2022 Aug 9;13:896899. doi: 10.3389/fphar.2022.896899. eCollection 2022.
Non-alcoholic fatty liver disease (NAFLD) is a liver disorder characterized by abnormal accumulation of hepatic fat and inflammatory response with complex pathogenesis. Over activation of the pyrin domain-containing protein 3 (NLRP3) inflammasome triggers the secretion of interleukin (IL)-1β and IL-18, induces pyroptosis, and promotes the release of a large number of pro-inflammatory proteins. All of which contribute to the development of NAFLD. There is a great deal of evidence indicating that plant-derived active ingredients are effective and safe for NAFLD management. This review aims to summarize the research progress of 31 active plant-derived components (terpenoids, flavonoids, alkaloids, and phenols) that alleviate lipid deposition, inflammation, and pyroptosis by acting on the NLRP3 inflammasome studied in both and NAFLD models. These studies confirmed that the NLRP3 inflammasome and its related genes play a key role in NAFLD amelioration, providing a starting point for further study on the correlation of plant-derived compounds treatment with the NLRP3 inflammasome and NAFLD.
非酒精性脂肪性肝病（NAFLD）是一种以肝脏脂肪异常蓄积和炎症反应为特征的肝脏疾病，其发病机制复杂。含pyrin结构域的蛋白3（NLRP3）炎性小体的过度激活会触发白细胞介素（IL）-1β和IL-18的分泌，诱导细胞焦亡，并促进大量促炎蛋白的释放。所有这些都有助于NAFLD的发展。有大量证据表明，植物源活性成分对NAFLD的管理是有效且安全的。本综述旨在总结31种植物源活性成分（萜类、黄酮类、生物碱类和酚类）的研究进展，这些成分通过作用于NLRP3炎性小体来减轻脂质沉积、炎症和细胞焦亡，相关研究在体内和体外NAFLD模型中均有开展。这些研究证实，NLRP3炎性小体及其相关基因在NAFLD改善中起关键作用，为进一步研究植物源化合物治疗与NLRP3炎性小体和NAFLD之间的相关性提供了一个起点。
