Kodama M, Kodama T, Ooki T
Nutr Cancer. 1987;9(4):237-49. doi: 10.1080/01635588709513932.
We investigated the effect of rice and salty rice diets on the physical growth and on the constitution of urinary steroids in Swiss/ICR mice. The following three kinds of diets were employed in the feeding experiment: 1) standard diet; 2) rice diet; and 3) salty rice diet. Long-term maintenance of mice on both rice and salty rice diets led to a relative increase of tetrahydrocortisol associated with a concomitant decrease of androgen, progestin, and cholesterol in urine. Evidence was presented to indicate that the activity of endogenous hydrocortisone in mice could be augmented by an increased intake of sodium chloride alone; there was also evidence that the glandular stomach of a young mouse drinking physiological saline is highly sensitive to a suppressive action of hydrocortisone. We concluded that the two experimental diets produced a state of catabolic glucocorticoid excess combined with a deficiency of anabolic androgen and progestin. Mineralocorticoid status was not examined. In the salty rice diet, a markedly lower weight gain was observed, whereas in the rice diet, in general, no significant weight changes were observed.
我们研究了大米和咸米饮食对瑞士/ICR小鼠身体生长及尿甾体成分的影响。在喂养实验中采用了以下三种饮食：1）标准饮食；2）大米饮食；3）咸米饮食。长期用大米和咸米饮食喂养小鼠会导致尿中四氢皮质醇相对增加，同时雄激素、孕激素和胆固醇减少。有证据表明，仅增加氯化钠的摄入量就能增强小鼠体内内源性氢化可的松的活性；也有证据表明，饮用生理盐水的幼鼠腺胃对氢化可的松的抑制作用高度敏感。我们得出结论，这两种实验性饮食产生了分解代谢的糖皮质激素过量状态，同时伴有合成代谢的雄激素和孕激素缺乏。未检测盐皮质激素状态。在咸米饮食组中，观察到体重增加明显较低，而在大米饮食组中，总体上未观察到显著的体重变化。
