Kodama M, Kodama T, Kobayashi S, Kasugai T, Takagi H, Suga S
Nutr Cancer. 1987;9(4):251-63. doi: 10.1080/01635588709513933.
We undertook a case-control study regarding the excretions of 14 urinary steroids in gastric cancer (GC) patients. The results are as follows: the levels of androgens, progestins, and two corticosteroids were, relative to tetrahydrocortisol, significantly depressed in GC patients of both sexes compared with the corresponding normal controls. The deviation profile of urinary steroids was not affected by radical gastrectomy. Evidence indicated that observed changes of GC urines were the steroidal expression of a decrease of endogenous testosterone combined with an increase of endogenous hydrocortisone; there was also evidence that the hormonal environment of our GC patients was endocrinologically homologous to that of rice-fed or salty rice-fed mice. Epidemiological inquiry revealed that GC patients having more access to rice-rich or salt-rich diets were taller and less obese than were rural healthy controls. In agreement with the anthropometric data of those cancer patients is the finding that the specific death rate of GC (as calculated for each of 15 prefectures of northern Japan) was positively correlated for each sex with the mean heights, but not with the mean weights, of 14-year-old youths of those areas. This paper discusses the possible relevancy of the hormonal and epidemiological aspects of GC patients to gastrocarcinogenesis in light of steroid physiology.
我们针对胃癌（GC）患者的14种尿甾体排泄情况进行了一项病例对照研究。结果如下：与相应的正常对照组相比，无论男女，GC患者体内雄激素、孕激素和两种皮质类固醇相对于四氢皮质醇的水平均显著降低。尿甾体的偏差情况不受根治性胃切除术的影响。有证据表明，GC患者尿液中观察到的变化是内源性睾酮减少与内源性氢化可的松增加的甾体表达；也有证据表明，我们的GC患者的激素环境在内分泌学上与以大米为食或高盐大米喂养的小鼠的激素环境相似。流行病学调查显示，与农村健康对照组相比，摄入富含大米或盐分饮食较多的GC患者身材更高且肥胖程度更低。与这些癌症患者的人体测量数据一致的是，GC的特定死亡率（按日本北部15个县分别计算）与各地区14岁青少年的平均身高呈正相关，但与平均体重无关。本文根据甾体生理学探讨了GC患者的激素和流行病学方面与胃癌发生的可能相关性。
