• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

蛋白质的过表达与三阴性乳腺癌密切相关。

Overexpression of protein is closely related to triple-negative breast cancer.

作者信息

Nam Sang Eun, Ko Young-Sin, Park Kyoung Sik, Jin TongYi, Yoo Young-Bum, Yang Jung-Hyun, Kim Wook-Youn, Han Hye-Seung, Lim So-Dug, Lee Seung Eun, Kim Wan-Seop

机构信息

Department of Surgery, Konkuk University School of Medicine, Seoul, Korea.

Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea.

出版信息

Ann Surg Treat Res. 2022 Aug;103(2):63-71. doi: 10.4174/astr.2022.103.2.63. Epub 2022 Aug 5.

DOI:10.4174/astr.2022.103.2.63
PMID:36017142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9365638/
Abstract

PURPOSE

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with a poor prognosis and a lack of targeted therapy. Overexpression of is thought to be associated with this aggressive subtype of cancer. Here, we performed a comprehensive analysis and assessed the association between overexpression of and TNBC.

METHODS

First, using different web-based bioinformatics platforms (TIMER 2.0, UALCAN, and GEPIA 2), the expression of was assessed. Then, the expression of the protein and hormone receptors and HER2 status were assessed by immunohistochemical analysis. For samples of tumors with equivocal immunoreactivity, we performed silver hybridization of the HER2 gene to determine an accurate HER2 status. Next, we used the R package and bc-GenExMiner 4.8 to analyze the relationship between expression and clinicopathological parameters in breast cancer patients. Finally, we determined the relationship between overexpression and prognosis in patients.

RESULTS

The expression of in breast cancer tissues is significantly higher than in normal tissue. expression was significantly related to worse overall survival (P < 0.05) and was correlated with these clinicopathological features: T stage, N stage, age, high histologic grade, estrogen receptor status, progesterone receptor status, Her-2 status, TNBC status, basal-like status, CK5/6 status, and Ki67 status.

CONCLUSION

was overexpressed in breast cancer compared to normal tissue, and it may be involved in the progression of breast cancer malignancy. This study provides suggestive evidence of the prognostic role of in breast cancer and the therapeutic target for TNBC.

摘要

目的

三阴性乳腺癌（TNBC）是一种侵袭性乳腺癌亚型，预后较差且缺乏靶向治疗。[具体基因名称]的过表达被认为与这种侵袭性癌症亚型相关。在此，我们进行了全面分析并评估了[具体基因名称]过表达与TNBC之间的关联。

方法

首先，使用不同的基于网络的生物信息学平台（TIMER 2.0、UALCAN和GEPIA 2）评估[具体基因名称]的表达。然后，通过免疫组织化学分析评估[具体基因名称]蛋白、激素受体和HER2状态的表达。对于免疫反应性不明确的肿瘤样本，我们进行HER2基因的银[具体技术名称]杂交以确定准确的HER2状态。接下来，我们使用R包和bc - GenExMiner 4.8分析[具体基因名称]表达与乳腺癌患者临床病理参数之间的关系。最后，我们确定了[具体基因名称]过表达与患者预后之间的关系。

结果

乳腺癌组织中[具体基因名称]的表达明显高于正常组织。[具体基因名称]表达与较差的总生存期显著相关（P < 0.05），并与这些临床病理特征相关：T分期、N分期、年龄、高组织学分级、雌激素受体状态、孕激素受体状态、Her - 2状态、TNBC状态、基底样状态、CK5/6状态和Ki67状态。

结论

与正常组织相比，[具体基因名称]在乳腺癌中过表达，并且它可能参与乳腺癌恶性进展。本研究为[具体基因名称]在乳腺癌中的预后作用和TNBC的治疗靶点提供了提示性证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/9365638/9ed746a747a2/astr-103-63-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/9365638/df7268b88226/astr-103-63-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/9365638/3a3b291a8fc5/astr-103-63-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/9365638/24ec6bade060/astr-103-63-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/9365638/f8a816e3b9d4/astr-103-63-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/9365638/09910d69369f/astr-103-63-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/9365638/a6e0f7aa0eb1/astr-103-63-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/9365638/9ed746a747a2/astr-103-63-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/9365638/df7268b88226/astr-103-63-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/9365638/3a3b291a8fc5/astr-103-63-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/9365638/24ec6bade060/astr-103-63-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/9365638/f8a816e3b9d4/astr-103-63-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/9365638/09910d69369f/astr-103-63-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/9365638/a6e0f7aa0eb1/astr-103-63-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/9365638/9ed746a747a2/astr-103-63-g007.jpg

相似文献

1
Overexpression of protein is closely related to triple-negative breast cancer.蛋白质的过表达与三阴性乳腺癌密切相关。
Ann Surg Treat Res. 2022 Aug;103(2):63-71. doi: 10.4174/astr.2022.103.2.63. Epub 2022 Aug 5.
2
Immunohistochemical co-expression status of cytokeratin 5/6, androgen receptor, and p53 as prognostic factors of adjuvant chemotherapy for triple negative breast cancer.细胞角蛋白5/6、雄激素受体和p53的免疫组化共表达状态作为三阴性乳腺癌辅助化疗的预后因素
Med Mol Morphol. 2016 Mar;49(1):11-21. doi: 10.1007/s00795-015-0109-0. Epub 2015 May 26.
3
Vitamin D receptor () mRNA overexpression is associated with poor prognosis in breast carcinoma.维生素D受体（）信使核糖核酸过表达与乳腺癌的不良预后相关。
Ann Surg Treat Res. 2022 Oct;103(4):183-194. doi: 10.4174/astr.2022.103.4.183. Epub 2022 Oct 7.
4
Stratification of Prognosis of Triple-Negative Breast Cancer Patients Using Combinatorial Biomarkers.使用组合生物标志物对三阴性乳腺癌患者的预后进行分层
PLoS One. 2016 Mar 1;11(3):e0149661. doi: 10.1371/journal.pone.0149661. eCollection 2016.
5
Gene Overexpression Is Associated with Poor Prognosis of Triple-Negative Breast Cancer Patients.基因过表达与三阴性乳腺癌患者预后不良相关。
Genet Test Mol Biomarkers. 2021 Mar;25(3):227-235. doi: 10.1089/gtmb.2020.0138.
6
Feline mammary basal-like adenocarcinomas: a potential model for human triple-negative breast cancer (TNBC) with basal-like subtype.猫乳腺基底样腺癌：一种具有基底样亚型的人类三阴性乳腺癌（TNBC）的潜在模型。
BMC Cancer. 2013 Sep 3;13:403. doi: 10.1186/1471-2407-13-403.
7
HER3 status by immunohistochemistry is correlated with poor prognosis in hormone receptor-negative breast cancer patients.免疫组织化学检测 HER3 状态与激素受体阴性乳腺癌患者的不良预后相关。
Breast Cancer Res Treat. 2013 Jun;139(3):741-50. doi: 10.1007/s10549-013-2570-6. Epub 2013 May 31.
8
Expression of SIRT1, SIRT3 and SIRT6 Genes for Predicting Survival in Triple-Negative and Hormone Receptor-Positive Subtypes of Breast Cancer.SIRT1、SIRT3 和 SIRT6 基因的表达对三阴性和激素受体阳性乳腺癌亚型生存的预测作用。
Pathol Oncol Res. 2020 Oct;26(4):2723-2731. doi: 10.1007/s12253-020-00873-5. Epub 2020 Jul 17.
9
Cyclooxygenase-2 expression in non-metastatic triple-negative breast cancer patients.非转移性三阴性乳腺癌患者中环氧合酶-2的表达
Mol Clin Oncol. 2014 Sep;2(5):845-850. doi: 10.3892/mco.2014.327. Epub 2014 Jun 23.
10
Triple negative breast cancer in Korea-distinct biology with different impact of prognostic factors on survival.韩国的三阴性乳腺癌——具有独特生物学特性的疾病，不同预后因素对生存的影响也不同。
Breast Cancer Res Treat. 2010 Aug;123(1):177-87. doi: 10.1007/s10549-010-0998-5. Epub 2010 Jun 24.

引用本文的文献

1
Computational pipeline predicting cell death suppressors as targets for cancer therapy.预测细胞死亡抑制因子作为癌症治疗靶点的计算流程。
iScience. 2024 Aug 30;27(9):110859. doi: 10.1016/j.isci.2024.110859. eCollection 2024 Sep 20.
2
Causal Relationship between Immune Cells and Gynecological Cancers through Bidirectional and Multivariable Mendelian Randomization Analyses.通过双向和多变量孟德尔随机化分析探讨免疫细胞与妇科癌症之间的因果关系
J Cancer. 2024 Feb 4;15(7):1880-1889. doi: 10.7150/jca.92627. eCollection 2024.

本文引用的文献

1
Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer.鉴定 BBOX1 为三阴性乳腺癌的治疗靶点。
Cancer Discov. 2020 Nov;10(11):1706-1721. doi: 10.1158/2159-8290.CD-20-0288. Epub 2020 Jul 20.
2
TIMER2.0 for analysis of tumor-infiltrating immune cells.TIMER2.0 用于分析肿瘤浸润免疫细胞。
Nucleic Acids Res. 2020 Jul 2;48(W1):W509-W514. doi: 10.1093/nar/gkaa407.
3
TPX2 as a Novel Prognostic Indicator and Promising Therapeutic Target in Triple-negative Breast Cancer.TPX2 作为三阴性乳腺癌的一种新型预后指标和有前途的治疗靶点。
Clin Breast Cancer. 2019 Dec;19(6):450-455. doi: 10.1016/j.clbc.2019.05.012. Epub 2019 Jun 13.
4
Cytokeratin 5/6 and cytokeratin 8/18 expression in triple negative breast cancers: clinicopathologic significance in South-Asian population.细胞角蛋白5/6和细胞角蛋白8/18在三阴性乳腺癌中的表达：南亚人群中的临床病理意义
BMC Res Notes. 2018 Jun 8;11(1):372. doi: 10.1186/s13104-018-3477-4.
5
Wnt7a Deficiency Could Predict Worse Disease-Free and Overall Survival in Estrogen Receptor-Positive Breast Cancer.Wnt7a基因缺失可预测雌激素受体阳性乳腺癌患者更差的无病生存期和总生存期。
J Breast Cancer. 2017 Dec;20(4):361-367. doi: 10.4048/jbc.2017.20.4.361. Epub 2017 Dec 19.
6
Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors.癌症中靶向Wnt/β-连环蛋白信号通路：效应物与抑制剂的最新进展
Cancer Treat Rev. 2018 Jan;62:50-60. doi: 10.1016/j.ctrv.2017.11.002. Epub 2017 Nov 13.
7
UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses.UALCAN：一个促进肿瘤亚组基因表达和生存分析的平台。
Neoplasia. 2017 Aug;19(8):649-658. doi: 10.1016/j.neo.2017.05.002. Epub 2017 Jul 18.
8
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses.GEPIA：一个用于癌症和正常基因表达谱分析及交互式分析的网络服务器。
Nucleic Acids Res. 2017 Jul 3;45(W1):W98-W102. doi: 10.1093/nar/gkx247.
9
FRAT1 expression regulates proliferation in colon cancer cells.FRAT1表达调控结肠癌细胞的增殖。
Oncol Lett. 2016 Dec;12(6):4761-4766. doi: 10.3892/ol.2016.5300. Epub 2016 Oct 19.
10
Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease.三阴性乳腺癌：一种异质性疾病的挑战与机遇
Nat Rev Clin Oncol. 2016 Nov;13(11):674-690. doi: 10.1038/nrclinonc.2016.66. Epub 2016 May 17.