Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Cancer Research, Nastran Center for Cancer Prevention (NCCP), Mashhad, Iran.
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Biomed Pharmacother. 2020 Sep;129:110459. doi: 10.1016/j.biopha.2020.110459. Epub 2020 Jun 30.
Studying prostate cancer is important due to its high annual incidences and mortality rates in the world. Although prostate cancer mortality rates are reduced using new therapy, complicated routes and side effects of these current drugs require a daily available treatment for prevention. Lycopene is a natural, prominent, and effective product which has a high value in diet. The anti-cancer effect, non-toxicity, safety and preventive or therapeutic roles of lycopene have been investigated in several studies. In the current review, we have collected information about the anti-cancer, anti-progressive and apoptotic effects of lycopene on prostate cancer. This article is a summary of the most important original and review articles on lycopene and its anticancer effects that are systematically categorized and presents information about the molecular structure, different sources, biological functions, and its in-vivo and in-vitro effects of lycopene on variety of cancerous and normal cells. The clinical studies provide a clear image for continuous use of this adjunctive dietary for different type of cancers, especially prostate cancer in men. In addition, this article discusses the various molecular pathways activated by lycopene that eventually prevent or suppress cancer. Lycopene has been found to effectively suppress the progression and proliferation, arrest in-cell cycle, and induce apoptosis of prostate cancer cells in both in-vivo and in-vitro conditions. Additionally, lycopene showed that it could modulate the signaling pathways and their protein for the treatment or prevention of prostate cancer.
研究前列腺癌很重要，因为它在世界范围内的年发病率和死亡率都很高。尽管新疗法降低了前列腺癌的死亡率，但这些现有药物的复杂途径和副作用需要一种日常可用的预防治疗方法。番茄红素是一种天然的、显著的、有效的产品，在饮食中有很高的价值。番茄红素的抗癌作用、无毒、安全性以及预防或治疗作用已在多项研究中得到了研究。在目前的综述中，我们收集了有关番茄红素对前列腺癌的抗癌、抗进展和凋亡作用的信息。本文综述了关于番茄红素及其抗癌作用的最重要的原始和综述文章，这些文章被系统地分类，并提供了有关番茄红素的分子结构、不同来源、生物学功能及其对多种癌细胞和正常细胞的体内和体外作用的信息。临床研究为连续使用这种辅助饮食治疗不同类型的癌症，特别是男性的前列腺癌，提供了清晰的图像。此外，本文还讨论了番茄红素激活的各种分子途径，最终可以预防或抑制癌症。番茄红素已被发现能有效地抑制前列腺癌细胞在体内和体外的进展和增殖、细胞周期停滞和诱导凋亡。此外，番茄红素还显示，它可以调节信号通路及其蛋白，用于治疗或预防前列腺癌。
