Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia.
Fraser's Hill Research Center, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.
Z Naturforsch C J Biosci. 2022 Aug 29;77(11-12):519-523. doi: 10.1515/znc-2022-0100. Print 2022 Nov 25.
Several species have exhibited potent biological activities such as anti-inflammatory, anti-angiogenesis, anticonvulsant, anti-obesity, and antiviral activities. However, the from Malaysia has not been investigated yet. Hence, this study aims to investigate the chemical composition and bioactivities of the essential oil of H.Keng from Malaysia. The hydrodistillation process was used to produce the essential oil, and gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) were used to analyse it. In total, 44 chemical components were identified in the bark oil, accounting for 98.4%. The major components of the essential oil were α-pinene (29.7%), elemol (10.2%), β-pinene (8.5%), β-caryophyllene (7.2%), α-terpineol (7.0%), guaiol (5.4%), and bulnesol (4.9%). Acetylcholinesterase and anti-inflammatory activities were also evaluated using the Ellman method and lipoxygenase enzyme, respectively, in which the essential oil showed moderate inhibitory activity against acetylcholinesterase (I%: 70.2%) and lipoxygenase (I%: 72.5%). Thus, the findings may be helpful for identifying the medicinal and therapeutic uses of the essential oil from the genus.
一些物种表现出了强大的生物活性，如抗炎、抗血管生成、抗惊厥、抗肥胖和抗病毒活性。然而，来自马来西亚的物种尚未得到研究。因此，本研究旨在研究马来西亚产的 essential oil 的化学成分和生物活性。采用水蒸馏法生产精油，并采用气相色谱（GC）和气相色谱-质谱联用（GC-MS）对其进行分析。共鉴定出树皮油中的 44 种化学成分，占 98.4%。精油的主要成分是α-蒎烯（29.7%）、艾醇（10.2%）、β-蒎烯（8.5%）、β-石竹烯（7.2%）、α-萜品醇（7.0%）、愈创木醇（5.4%）和布内醇（4.9%）。采用 Ellman 法和脂氧合酶分别评估了乙酰胆碱酯酶和抗炎活性，结果表明，精油对乙酰胆碱酯酶（I%：70.2%）和脂氧合酶（I%：72.5%）具有中等抑制活性。因此，这些发现可能有助于确定该属精油的药用和治疗用途。
