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[乙酰-α-肉碱与氯磺丙脲在实验性糖尿病中降血糖活性的比较评估]

[A comparative evaluation of the hypoglycemic activity of acetyl-alpha-carnitine and chlorpropamide in experimental diabetes].

作者信息

Kim E K, Trevisani K, Trevisani M, Suslina Z A, Seĭfulla R D

出版信息

Eksp Klin Farmakol. 1994 Jul-Aug;57(4):52-3.

PMID:7950787
Abstract

The comparison of the action shown by acetyl-alpha-carnitine and chloropropamide in rabbits with experimental diabetes has demonstrated that the former has a more pronounced hypoglycemic action. In combined administration, acetyl-alpha-carnitine substantially enhanced the effects of chloropropamide in the animals with experimental diabetes, which should be taken into account by clinicians in its use.

摘要

对乙酰-α-肉碱和氯磺丙脲在实验性糖尿病兔身上所表现出的作用进行比较后发现,前者具有更显著的降血糖作用。在联合给药时,乙酰-α-肉碱可显著增强氯磺丙脲对实验性糖尿病动物的作用,临床医生在使用时应考虑到这一点。

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