有证据表明自发有丝分裂重组发生在双链阶段。
Evidence that spontaneous mitotic recombination occurs at the two-strand stage.
作者信息
Esposito M S
出版信息
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4436-40. doi: 10.1073/pnas.75.9.4436.
Abstract
Spontaneous reciprocal mitotic recombination in the yeast Saccharomyces cerevisiae, associated with heteroallelic recombination, occurs almost exclusively at the two-strand stage and involves recombination of unduplicated chromosomes (i.e., during G1) or the unduplicated regions of chromosomes during the S phase of mitosis. The associated heteroallelic recombination frequently reflects the formation of symmetric Holliday structures, is not strongly polarized with respect to conversion at the heteroallelic trp5 sites studied, occasionally results in simultaneous conversion of widely separated genetic markers, and is positively correlated with recombination of flanking markers.
摘要
酿酒酵母中的自发相互有丝分裂重组与杂合等位基因重组相关，几乎只发生在双链阶段，涉及未复制染色体的重组（即G1期）或有丝分裂S期染色体的未复制区域。相关的杂合等位基因重组常常反映出对称霍利迪结构的形成，在所研究的杂合等位基因trp5位点上，转换方面没有强烈的极性，偶尔会导致广泛分离的遗传标记同时转换，并且与侧翼标记的重组呈正相关。
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