Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of tumor microenvironment responsive drug research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Phytother Res. 2022 Nov;36(11):4080-4100. doi: 10.1002/ptr.7590. Epub 2022 Aug 27.
Atherosclerosis is the onset of endothelial cell damage and is characterized by abnormal accumulation of fibrinogen and lipid in large and middle arteries. Recent researches indicate that traditional Chinese medicine including Notoginseng Radix et Rhizoma, Astragali Radix, Salviae Miltiorrhizae Radix et Rhizoma, Ginseng Radix et Rhizoma, Fructus Crataegi, Glycyrrhizae Radix et Rhizoma, Polygoni Multiflori Radix, Fructus Lycii, and Coptidis Rhizoma have therapeutic effects on atherosclerosis. Furthermore, the pharmacological roles of these kinds of traditional Chinese medicine in atherosclerosis refer to endothelial function influences, cell proliferation and migration, platelet aggregation, thrombus formation, oxidative stress, inflammation, angiogenesis, apoptosis, autophagy, lipid metabolism, and the gut microbiome. Traditional Chinese medicine may serve as potential and effective anti-atherosclerosis drugs. However, a critical study has shown that Notoginseng Radix et Rhizoma may also have toxic effects including pustules, fever, and elevate circulating neutrophil count. Further high-quality studies are still required to determine the clinical safety and efficacy of traditional Chinese medicine and its active ingredients.
动脉粥样硬化是内皮细胞损伤的开始，其特征是在大动脉和中动脉中纤维蛋白原和脂质的异常积聚。最近的研究表明，包括三七、黄芪、丹参、人参、山楂、甘草、何首乌、枸杞和黄连在内的中药对动脉粥样硬化具有治疗作用。此外，这些中药在动脉粥样硬化中的药理作用涉及内皮功能影响、细胞增殖和迁移、血小板聚集、血栓形成、氧化应激、炎症、血管生成、细胞凋亡、自噬、脂质代谢和肠道微生物组。中药可能作为一种有潜力和有效的抗动脉粥样硬化药物。然而，一项关键性研究表明，三七也可能具有毒性作用，包括脓疱、发热和循环中性粒细胞计数升高。仍需要高质量的研究来确定中药及其活性成分的临床安全性和疗效。
