Wang Xue, Qian Lilin, Qiao Yanan, Jin Xueyang, Zhou Jinchuan, Yuan Shuangzhi, Zhang Jiaozhen, Zhang Chunyang, Lou Hongxiang
Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China.
Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China.
Phytochemistry. 2022 Nov;203:113376. doi: 10.1016/j.phytochem.2022.113376. Epub 2022 Aug 24.
A chemical investigation of the Chinese liverwort Chandonanthus birmensis Steph identified five undescribed cembrane-type diterpenoids, together with six known cembrane diterpenes, one fusicoccane-type diterpenoid, and a dolabellane-type diterpenoid. Their structures were established by comprehensive analysis of HRESIMS, NMR spectroscopic data, electronic circular dichroism (ECD) calculations and single-crystal X-ray diffraction analysis. Cytotoxicity tests of the isolated diterpenoids against five cancer cell lines (A2780, A549, H460, H460RT, and HeLa) revealed that several compounds showed moderate inhibitory effects with IC values ranging from 11.1 to 36.2 μM.
对中国产苔藓植物缅甸钱袋苔（Chandonanthus birmensis Steph）进行的化学研究，鉴定出了5种未描述的cembrane型二萜类化合物，以及6种已知的cembrane二萜、1种fusicoccane型二萜类化合物和1种dolabellane型二萜类化合物。通过对高分辨电喷雾电离质谱（HRESIMS）、核磁共振光谱数据、电子圆二色光谱（ECD）计算和单晶X射线衍射分析的综合分析确定了它们的结构。对分离得到的二萜类化合物针对5种癌细胞系（A2780、A549、H460、H460RT和HeLa）进行的细胞毒性测试表明，几种化合物表现出中等抑制作用，IC值范围为11.1至36.2 μM。
