Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Anatomical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Cell Biol Int. 2022 Nov;46(11):1717-1728. doi: 10.1002/cbin.11896. Epub 2022 Aug 28.
Malignantly transformed cells must alter their metabolic status to stay viable in a harsh microenvironment and maintain their ability to invade and spread. Anoikis, a specific detachment-related form of apoptotic cell death, is a potential barrier to cancer cell metastasis. Several molecular/pathway alterations have been implicated in preventing anoikis in metastatic cancers. Specific alterations in the lipid metabolism machinery (such as an increase in fatty acid uptake and synthesis) and modifications in the carbohydrate and amino acid metabolism are partially identified mechanisms associated with the anoikis resistance in various types of cancers, among other survival benefits. Following a summary of the molecular basis of the anoikis pathway, its resistance mechanisms, and the fundamentals of lipid metabolism in cancer, this article aims to elucidate the impact of lipid metabolism deviations recruited by cancer cells to escape anoikis.
恶性转化细胞必须改变其代谢状态，以在恶劣的微环境中保持存活，并维持其侵袭和扩散的能力。失巢凋亡是一种特定的与脱离相关的细胞凋亡形式，是癌症细胞转移的潜在障碍。有几种分子/途径的改变被认为可以防止转移性癌症中的失巢凋亡。脂质代谢机制中的特定改变（如脂肪酸摄取和合成的增加）以及碳水化合物和氨基酸代谢的修饰，是与各种类型癌症中的失巢凋亡抵抗相关的部分确定机制，以及其他生存益处。在总结了失巢凋亡途径的分子基础、其抵抗机制以及癌症中脂质代谢的基础之后，本文旨在阐明癌细胞逃避失巢凋亡所招募的脂质代谢偏差的影响。
