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学习引起运动序列执行的神经回路的变化。

Learning-induced changes in the neural circuits underlying motor sequence execution.

机构信息

Department of Organismic and Evolutionary Biology and Center for Brain Science, Harvard University. Electronic address: https://twitter.com/@NKadmonHarpaz.

Department of Organismic and Evolutionary Biology and Center for Brain Science, Harvard University. Electronic address: https://twitter.com/@kiahhardcastle.

出版信息

Curr Opin Neurobiol. 2022 Oct;76:102624. doi: 10.1016/j.conb.2022.102624. Epub 2022 Aug 26.

DOI:10.1016/j.conb.2022.102624
PMID:36030613
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11125547/
Abstract

As the old adage goes: practice makes perfect. Yet, the neural mechanisms by which rote repetition transforms a halting behavior into a fluid, effortless, and "automatic" action are not well understood. Here we consider the possibility that well-practiced motor sequences, which initially rely on higher-level decision-making circuits, become wholly specified in lower-level control circuits. We review studies informing this idea, discuss the constraints on such shift in control, and suggest approaches to pinpoint circuit-level changes associated with motor sequence learning.

摘要

常言道

熟能生巧。然而,我们对于重复练习是如何将一个生硬的行为转变为流畅、毫不费力且“自动化”的动作的神经机制还知之甚少。在这里,我们考虑了一种可能性,即经过充分练习的运动序列最初依赖于更高层次的决策回路,而最终完全由较低层次的控制回路来指定。我们回顾了支持这一观点的研究,并讨论了这种控制转变的限制,同时还提出了一些方法来确定与运动序列学习相关的回路水平变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dd8/11125547/5124fabb868a/nihms-1994799-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dd8/11125547/9b4b74d700a2/nihms-1994799-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dd8/11125547/75451cb73984/nihms-1994799-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dd8/11125547/5124fabb868a/nihms-1994799-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dd8/11125547/9b4b74d700a2/nihms-1994799-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dd8/11125547/75451cb73984/nihms-1994799-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dd8/11125547/5124fabb868a/nihms-1994799-f0003.jpg

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Cortical processing of flexible and context-dependent sensorimotor sequences.灵活且依赖上下文的感觉运动序列的皮质处理。
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Distinct roles for motor cortical and thalamic inputs to striatum during motor skill learning and execution.在运动技能学习与执行过程中,运动皮层和丘脑输入纹状体的不同作用。
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Cortical preparatory activity indexes learned motor memories.皮质准备活动索引习得的运动记忆。
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