Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands; Department of Radiology, C.J. Gorter MRI Center, Leiden, the Netherlands.
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands; Department of Physical Education and Sport, Faculty of Sport Sciences, PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute(iMUDS), University of Granada, Granada, Spain; Department of Education, Faculty of Education Sciences and SPORT Research Group(CTS-1024), CERNEP Research Center, University of Almería, Almería, Spain.
J Therm Biol. 2022 Aug;108:103277. doi: 10.1016/j.jtherbio.2022.103277. Epub 2022 Jun 7.
Brown adipose tissue (BAT) increases metabolic heat production in response to cold exposure. Body size and composition are involved in the human cold response, yet the influence of BAT herein have not fully been explored. Here, we aimed to study the association of the cold-induced shivering threshold time with body composition, BAT, the perception of shivering and skin temperature in young adults.
110 young healthy adults (81 females; age = 21.7 ± 2.1 years, BMI = 24.2 ± 4.3 kg/m) underwent 2 h of individualized cooling, followed by the quantification of BAT using aF-fluorodeoxyglucose ([F]FDG) positron emission tomography-computed tomography (PET-CT) scan. Body mass index (BMI), lean mass, fat mass and body surface area (BSA) were also measured. Shivering threshold time was defined as the time until shivering occurred using an individualized cooling protocol.
The shivering threshold time was on average 116.1 min for males and 125.8 min for females, and was positively associated to BMI (β = 3.106; R = 0.141; p = 0.001), lean mass (β = 2.295; R = 0.128; p = 0.001) and fat mass (β = 1.492; R = 0.121; p = 0.001) in females, but not in males (all p ≥ 0.409). The shivering threshold time was positively associated with BSA in males (p = 0.047) and females (p = 0.001), but it was not associated with BAT volume or [F]FDG uptake nor with the perception of shivering and skin temperature perception in both sexes.
The shivering threshold time is positively associated with whole-body adiposity and lean mass in females, but not in males. The shivering threshold time was positively associated with BSA, but no association was observed with BAT nor with the perception of shivering or skin temperature. Future research should consider the influence of body composition when applying cooling protocols among individuals with different phenotypical features.
棕色脂肪组织（BAT）会在受到寒冷刺激时增加代谢产热。人体的体型和组成成分会影响对寒冷的反应，但 BAT 在此过程中的影响尚未得到充分探索。本研究旨在探究年轻人的冷刺激颤抖阈时间与身体成分、BAT、颤抖感知和皮肤温度之间的关联。
110 名年轻健康成年人（81 名女性；年龄=21.7±2.1 岁，BMI=24.2±4.3kg/m）接受 2 小时的个体化冷却，随后使用氟-18 氟代脱氧葡萄糖 ([F]FDG) 正电子发射断层扫描-计算机断层扫描 (PET-CT) 扫描来量化 BAT。还测量了体重指数（BMI）、瘦体重、脂肪量和体表面积（BSA）。颤抖阈时间定义为使用个体化冷却方案直至出现颤抖的时间。
男性的颤抖阈时间平均为 116.1 分钟，女性为 125.8 分钟，与 BMI（β=3.106；R=0.141；p=0.001）、瘦体重（β=2.295；R=0.128；p=0.001）和脂肪量（β=1.492；R=0.121；p=0.001）呈正相关，但在男性中无相关性（p≥0.409）。颤抖阈时间与男性（p=0.047）和女性（p=0.001）的 BSA 呈正相关，但与 BAT 体积或 [F]FDG 摄取以及两性的颤抖感知和皮肤温度感知均无相关性。
颤抖阈时间与女性的全身肥胖和瘦体重呈正相关，但与男性无关。颤抖阈时间与 BSA 呈正相关，但与 BAT 或颤抖感知或皮肤温度感知均无相关性。未来的研究在针对不同表型特征的个体应用冷却方案时，应考虑身体成分的影响。
Zotero 插件