Department of Parasitology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia; A*STAR Infectious Diseases Labs, Agency for Science, Technology, and Research (A*STAR), Singapore.
Department of Microbiology and Immunology, University of Otago, Dunedin, Otago, New Zealand.
Trends Parasitol. 2022 Oct;38(10):882-889. doi: 10.1016/j.pt.2022.08.001. Epub 2022 Aug 26.
The ability of the intraerythrocytic Plasmodium spp. to form spontaneous rosettes with uninfected red blood cells (URBCs) has been observed in the medically important malaria parasites. Since the discovery of rosettes in the late 1980s, different formation mechanisms and pathobiological roles have been postulated for rosetting; most of which have focused on Plasmodium falciparum. Recent breakthroughs, including new data from Plasmodium vivax, have highlighted the multifaceted roles of rosetting in the immunopathobiology and the development of drug resistance in human malaria. Here, we provide new perspectives on the formation and the role of rosetting in malaria rheopathobiology.
在医学上重要的疟原虫中，已经观察到疟原虫在红细胞内形成与未感染的红细胞（URBC）自发玫瑰花结的能力。自 20 世纪 80 年代末发现玫瑰花结以来，人们提出了不同的形成机制和病理生物学作用来解释玫瑰花结的形成；其中大多数都集中在恶性疟原虫上。最近的突破，包括来自间日疟原虫的新数据，突出了玫瑰花结在免疫病理生物学和人类疟疾耐药性发展中的多方面作用。在这里，我们提供了关于疟疾病理生物学中玫瑰花结形成和作用的新视角。
