School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, People's Republic of China.
Department of Microbiology, Harvard Medical School, Boston, MA, USA.
Emerg Microbes Infect. 2022 Dec;11(1):2340-2349. doi: 10.1080/22221751.2022.2119168.
() is a Gram-positive, spore-forming, toxin-producing, obligate anaerobic bacterium. infection (CDI) is the leading cause of healthcare-associated infective diarrhoea. The infection is mediated by the spore, a metabolically inactive form of . The spore coat acts as a physical barrier to defend against chemical insults from hosts and natural environments. The composition of spore coat has already been revealed; therefore, the interactive networks of spore coat proteins and the dynamic process of coat assembly are the keys to design strategies to control and cure CDI. This review gives a brief discussion of the signal processing and transcriptional regulation of sporulation initiation. Following the discussion, the spore formation is also introduced. Finally, this review mainly focuses on the spore coat assembly, a poorly understood process in , and important proteins that have been studied.
() 是一种革兰氏阳性、产芽孢、产毒、专性厌氧细菌。感染（CDI）是导致医疗保健相关感染性腹泻的主要原因。感染是由芽孢介导的，芽孢是一种代谢不活跃的形式。芽孢外壳充当物理屏障，抵御来自宿主和自然环境的化学刺激。芽孢外壳的组成已经被揭示；因此，芽孢外壳蛋白的相互作用网络和外壳组装的动态过程是设计控制和治疗 CDI 的策略的关键。本文简要讨论了孢子形成起始的信号处理和转录调控。讨论之后，还介绍了孢子的形成。最后，本文主要关注的是在 中了解甚少的孢子外壳组装过程，以及已经研究过的重要蛋白质。
