Kilimanjaro Christian Medical Centre, Moshi, Kilimanjaro, Tanzania.
Centre for International Health University of Bergen, Bergen Norway.
Afr Health Sci. 2022 Mar;22(1):269-284. doi: 10.4314/ahs.v22i1.34.
The burden of neurological disorders is large and altered by the HIV epidemic.
We describe the pattern of neurological disorders and their association with HIV infection in adult patients attending a consultant hospital in Northern Tanzania.
In this prospective cross-sectional study, we collected data on adult neurological referrals over a 6-year period between 2007-13. The odds of HIV infection, across neurological categories adjusted for age and sex, was calculated.
Of 2037 participants, 54.8% were male and 45.2% were female. The median age of participants was 43 years. The results for HIV screening were available for 992/2037 (48.7%) patients, of whom 306 (30.8%) were seropositive. The most frequent neurological disorders were cerebrovascular disease (19.9%), paraplegia (13.6%), and peripheral neuropathies (8%). Taken together CNS infection accounted for 278/2037 (13.6%). The adjusted odds (aOR) of HIV infection was highest amongst infections; brain abscesses (aOR 107, 95% CI 35.1-470.4) and meningitis/encephalitis (aOR 40.1, 95% CI 13.6-172.9), but also raised in cerebrovascular disease, paraplegia, peripheral neuropathies, cranial nerve palsies, seizures, cerebllar disorders, movement disorders, motor neuron disease and headache.
The main pattern of neurological disorders in Northern Tanzania is presented. The odds of HIV infection was highest in CNS infections and in a wide range of non-communicable neurological disorders.
神经障碍的负担很大，并且受到 HIV 流行的影响。
我们描述了坦桑尼亚北部一家顾问医院就诊的成年患者的神经障碍模式及其与 HIV 感染的关联。
在这项为期 6 年的前瞻性横断面研究中，我们收集了 2007-13 年间成年神经转诊患者的数据。根据年龄和性别，对各神经类别中的 HIV 感染几率进行了调整。
在 2037 名参与者中，54.8%为男性，45.2%为女性。参与者的中位年龄为 43 岁。对 2037 例患者中的 992 例（48.7%）进行了 HIV 筛查，其中 306 例（30.8%）为阳性。最常见的神经障碍是脑血管病（19.9%）、截瘫（13.6%）和周围神经病（8%）。总的来说，中枢神经系统感染占 2037 例中的 278 例（13.6%）。HIV 感染的调整后比值比（aOR）在感染中最高；脑脓肿（aOR 107，95%CI 35.1-470.4）和脑膜炎/脑炎（aOR 40.1，95%CI 13.6-172.9），但也在脑血管病、截瘫、周围神经病、颅神经麻痹、癫痫、小脑疾病、运动障碍、运动神经元病和头痛中升高。
提出了坦桑尼亚北部神经障碍的主要模式。HIV 感染的几率在中枢神经系统感染和广泛的非传染性神经障碍中最高。
